Francisco J. Sánchez-Rivera

Francisco J. Sánchez-Rivera

Assistant Professor of Biology

Francisco J. Sánchez-Rivera aims to understand how genetic variation shapes normal physiology and disease, with a focus on cancer.

617-715-3389

Phone

76-361A

Office

fsr@mit.edu

Email

Ryan Hayman

Assistant

617-253-0796

Assistant Phone

Education

  • PhD, 2016, Biology, MIT
  • BS, 2008, Microbiology, University of Puerto Rico at Mayagüez

Research Summary

The overarching goal of the Sánchez-Rivera laboratory is to elucidate the cellular and molecular mechanisms by which genetic variation shapes normal physiology and disease, particularly in the context of cancer. To do so, we develop and apply genome engineering technologies, genetically-engineered mouse models (GEMMs), and single cell lineage tracing and omics approaches to obtain comprehensive biological pictures of disease evolution at single cell resolution. By doing so, we hope to produce actionable discoveries that could pave the way for better therapeutic strategies to treat cancer and other diseases.

Awards

  • Hanna H. Gray Fellowship, Howard Hughes Medical Institute, 2018-2026
  • GMTEC Postdoctoral Researcher Innovation Grant, Memorial Sloan Kettering Cancer Center, 2020-2022
  • 100 inspiring Hispanic/Latinx scientists in America, Cell Mentor/Cell Press, 2020

Key Publications

Recent Publications

  1. TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion. Shakiba, M, Zumbo, P, Espinosa-Carrasco, G, Menocal, L, Dündar, F, Carson, SE, Bruno, EM, Sanchez-Rivera, FJ, Lowe, SW, Camara, S et al.. 2022. J Exp Med 219, .
    doi: 10.1084/jem.20201966PMID:34935874
  2. An autoimmune stem-like CD8 T cell population drives type 1 diabetes. Gearty, SV, Dündar, F, Zumbo, P, Espinosa-Carrasco, G, Shakiba, M, Sanchez-Rivera, FJ, Socci, ND, Trivedi, P, Lowe, SW, Lauer, P et al.. 2021. Nature , .
    doi: 10.1038/s41586-021-04248-xPMID:34847567
  3. Replication and single-cycle delivery of SARS-CoV-2 replicons. Ricardo-Lax, I, Luna, JM, Thao, TTN, Le Pen, J, Yu, Y, Hoffmann, HH, Schneider, WM, Razooky, BS, Fernandez-Martinez, J, Schmidt, F et al.. 2021. Science 374, 1099-1106.
    doi: 10.1126/science.abj8430PMID:34648371
  4. Smarca4 Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung. Concepcion, CP, Ma, S, LaFave, LM, Bhutkar, A, Liu, M, DeAngelo, LP, Kim, JY, Del Priore, I, Schoenfeld, AJ, Miller, M et al.. 2021. Cancer Discov , .
    doi: 10.1158/2159-8290.CD-21-0248PMID:34561242
  5. Rlf-Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer. Ciampricotti, M, Karakousi, T, Richards, AL, Quintanal-Villalonga, À, Karatza, A, Caeser, R, Costa, EA, Allaj, V, Manoj, P, Spainhower, KB et al.. 2021. Cancer Discov , .
    doi: 10.1158/2159-8290.CD-21-0441PMID:34344693
  6. Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Sánchez-Rivera, FJ, Ryan, J, Soto-Feliciano, YM, Clare Beytagh, M, Xuan, L, Feldser, DM, Hemann, MT, Zamudio, J, Dimitrova, N, Letai, A et al.. 2021. Proc Natl Acad Sci U S A 118, .
    doi: 10.1073/pnas.2019740118PMID:34074758
  7. Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks. Schneider, WM, Luna, JM, Hoffmann, HH, Sánchez-Rivera, FJ, Leal, AA, Ashbrook, AW, Le Pen, J, Ricardo-Lax, I, Michailidis, E, Peace, A et al.. 2021. Cell 184, 120-132.e14.
    doi: 10.1016/j.cell.2020.12.006PMID:33382968
  8. Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors. Hoffmann, HH, Sánchez-Rivera, FJ, Schneider, WM, Luna, JM, Soto-Feliciano, YM, Ashbrook, AW, Le Pen, J, Leal, AA, Ricardo-Lax, I, Michailidis, E et al.. 2021. Cell Host Microbe 29, 267-280.e5.
    doi: 10.1016/j.chom.2020.12.009PMID:33357464
  9. Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function. Jiang, T, Sánchez-Rivera, FJ, Soto-Feliciano, YM, Yang, Q, Song, CQ, Bhuatkar, A, Haynes, CM, Hemann, MT, Xue, W. 2021. Hepatology 74, 233-247.
    doi: 10.1002/hep.31685PMID:33336367
  10. Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks. Schneider, WM, Luna, JM, Hoffmann, HH, Sánchez-Rivera, FJ, Leal, AA, Ashbrook, AW, Le Pen, J, Michailidis, E, Ricardo-Lax, I, Peace, A et al.. 2020. bioRxiv , .
    doi: 10.1101/2020.10.07.326462PMID:33052332
More Publications
Photo credit: Adam Lerner