Education
- PhD, 2016, Biology, MIT
- BS, 2008, Microbiology, University of Puerto Rico at Mayagüez
Research Summary
The overarching goal of the Sánchez-Rivera laboratory is to elucidate the cellular and molecular mechanisms by which genetic variation shapes normal physiology and disease, particularly in the context of cancer. To do so, we develop and apply genome engineering technologies, genetically-engineered mouse models (GEMMs), and single cell lineage tracing and omics approaches to obtain comprehensive biological pictures of disease evolution at single cell resolution. By doing so, we hope to produce actionable discoveries that could pave the way for better therapeutic strategies to treat cancer and other diseases.
Awards
- V Foundation Award, 2022
- Hanna H. Gray Fellowship, Howard Hughes Medical Institute, 2018-2026
- GMTEC Postdoctoral Researcher Innovation Grant, Memorial Sloan Kettering Cancer Center, 2020-2022
- 100 inspiring Hispanic/Latinx scientists in America, Cell Mentor/Cell Press, 2020
Key Publications
- A prime editor mouse to model a broad spectrum of somatic mutations in vivo. Ely, ZA, Mathey-Andrews, N, Naranjo, S, Gould, SI, Mercer, KL, Newby, GA, Cabana, CM, Rideout, WM 3rd, Jaramillo, GC, Khirallah, JM et al.. 2023. Nat Biotechnol , .
doi: 10.1038/s41587-023-01783-yPMID:37169967 - Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Sánchez-Rivera, FJ, Diaz, BJ, Kastenhuber, ER, Schmidt, H, Katti, A, Kennedy, M, Tem, V, Ho, YJ, Leibold, J, Paffenholz, SV et al.. 2022. Nat Biotechnol 40, 862-873.
doi: 10.1038/s41587-021-01172-3PMID:35165384 - Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1. Romero, R, Sánchez-Rivera, FJ, Westcott, PMK, Mercer, KL, Bhutkar, A, Muir, A, González Robles, TJ, Lamboy Rodríguez, S, Liao, LZ, Ng, SR et al.. 2020. Nat Cancer 1, 589-602.
doi: 10.1038/s43018-020-0071-1PMID:34414377 - Rapid modelling of cooperating genetic events in cancer through somatic genome editing. Sánchez-Rivera, FJ, Papagiannakopoulos, T, Romero, R, Tammela, T, Bauer, MR, Bhutkar, A, Joshi, NS, Subbaraj, L, Bronson, RT, Xue, W et al.. 2014. Nature 516, 428-31.
doi: 10.1038/nature13906PMID:25337879 - High throughput evaluation of genetic variants with prime editing sensor libraries. Gould, S.I, Wuest, A.N., Dong, K., Johnson, G.A., Hsu, A., Narendra, V.K., Levine, S.S., Liu, D.R., and Sanchez-Rivera, F.J. 2023. bioRxiv.
doi: https://doi.org/10.1101/2022.10.26.513842
Recent Publications
- Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability. Benabdallah, NS, Dalal, V, Scott, RW, Marcous, F, Sotiriou, A, Kommoss, FKF, Pejkovska, A, Gaspar, L, Wagner, L, Sánchez-Rivera, FJ et al.. 2023. Nat Struct Mol Biol , .
doi: 10.1038/s41594-023-01096-3PMID:37735617 - Generation of precision preclinical cancer models using regulated in vivo base editing. Katti, A, Vega-Pérez, A, Foronda, M, Zimmerman, J, Zafra, MP, Granowsky, E, Goswami, S, Gardner, EE, Diaz, BJ, Simon, JM et al.. 2023. Nat Biotechnol , .
doi: 10.1038/s41587-023-01900-xPMID:37563300 - How CRISPR Is Revolutionizing the Generation of New Models for Cancer Research. Sánchez Rivera, FJ, Dow, LE. 2023. Cold Spring Harb Perspect Med , .
doi: 10.1101/cshperspect.a041384PMID:37487630 - Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma. Chen, X, Li, Y, Zhu, F, Xu, X, Estrella, B, Pazos, MA 2nd, McGuire, JT, Karagiannis, D, Sahu, V, Mustafokulov, M et al.. 2023. Nat Commun 14, 4259.
doi: 10.1038/s41467-023-39990-5PMID:37460547 - A prime editor mouse to model a broad spectrum of somatic mutations in vivo. Ely, ZA, Mathey-Andrews, N, Naranjo, S, Gould, SI, Mercer, KL, Newby, GA, Cabana, CM, Rideout, WM 3rd, Jaramillo, GC, Khirallah, JM et al.. 2023. Nat Biotechnol , .
doi: 10.1038/s41587-023-01783-yPMID:37169967 - Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors. Karagiannis, D, Wu, W, Li, A, Hayashi, M, Chen, X, Yip, M, Mangipudy, V, Xu, X, Sánchez-Rivera, FJ, Soto-Feliciano, YM et al.. 2023. bioRxiv , .
doi: 10.1101/2023.04.24.538118PMID:37162970 - STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma. Hu, J, Sánchez-Rivera, FJ, Wang, Z, Johnson, GN, Ho, YJ, Ganesh, K, Umeda, S, Gan, S, Mujal, AM, Delconte, RB et al.. 2023. Nature 616, 806-813.
doi: 10.1038/s41586-023-05880-5PMID:36991128 - A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition. Soto-Feliciano, YM, Sánchez-Rivera, FJ, Perner, F, Barrows, DW, Kastenhuber, ER, Ho, YJ, Carroll, T, Xiong, Y, Anand, D, Soshnev, AA et al.. 2023. Cancer Discov 13, 146-169.
doi: 10.1158/2159-8290.CD-22-0416PMID:36264143 - A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets. Li, X, Huang, CH, Sánchez-Rivera, FJ, Kennedy, MC, Tschaharganeh, DF, Morris, JP 4th, Montinaro, A, O'Rourke, KP, Banito, A, Wilkinson, JE et al.. 2022. Proc Natl Acad Sci U S A 119, e2110557119.
doi: 10.1073/pnas.2110557119PMID:35442775 - Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Sánchez-Rivera, FJ, Diaz, BJ, Kastenhuber, ER, Schmidt, H, Katti, A, Kennedy, M, Tem, V, Ho, YJ, Leibold, J, Paffenholz, SV et al.. 2022. Nat Biotechnol 40, 862-873.
doi: 10.1038/s41587-021-01172-3PMID:35165384 - High throughput evaluation of genetic variants with prime editing sensor libraries. Gould, S.I, Wuest, A.N., Dong, K., Johnson, G.A., Hsu, A., Narendra, V.K., Levine, S.S., Liu, D.R., and Sanchez-Rivera, F.J. 2023. bioRxiv.
doi: https://doi.org/10.1101/2022.10.26.513842
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