Education
- PhD, 2016, Biology, MIT
- BS, 2008, Microbiology, University of Puerto Rico at Mayagüez
Research Summary
The overarching goal of the Sánchez-Rivera laboratory is to elucidate the cellular and molecular mechanisms by which genetic variation shapes normal physiology and disease, particularly in the context of cancer. To do so, we develop and apply genome engineering technologies, genetically-engineered mouse models (GEMMs), and single cell lineage tracing and omics approaches to obtain comprehensive biological pictures of disease evolution at single cell resolution. By doing so, we hope to produce actionable discoveries that could pave the way for better therapeutic strategies to treat cancer and other diseases.
Awards
- V Foundation Award, 2022
- Hanna H. Gray Fellowship, Howard Hughes Medical Institute, 2018-2026
- GMTEC Postdoctoral Researcher Innovation Grant, Memorial Sloan Kettering Cancer Center, 2020-2022
- 100 inspiring Hispanic/Latinx scientists in America, Cell Mentor/Cell Press, 2020
Key Publications
Recent Publications
- Integrated chronic in vivo and in vitro screens uncover NFIL3 as a driver of T cell dysfunction. Jain, N, Shi, Y, May, C, Mitra, S, Bucher, P, Dobrin, A, Zhao, Z, Hanina, S, Rajasekhar, VK, Yao, Y et al.. 2026. Cancer Discov , .
doi: 10.1158/2159-8290.CD-25-1524PMID:41747243 - The integrated stress response promotes immune evasion through lipocalin 2. Bossowski, JP, Pillai, R, Kilian, J, Wong Lau, A, Nakamura, M, Rashidfarrokhi, A, Hao, Y, Li, R, Wu, K, Hattori, T et al.. 2026. Nature , .
doi: 10.1038/s41586-026-10143-0PMID:41708864 - Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Mazur, PK, Herner, A, Mello, SS, Wirth, M, Hausmann, S, Sánchez-Rivera, FJ, Lofgren, SM, Kuschma, T, Hahn, SA, Vangala, D et al.. 2026. Nat Med 32, 763-764.
doi: 10.1038/s41591-026-04234-8PMID:41611992 - Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network. Halim, S, Sebastian, RM, Liivak, KE, Patrick, JE, Hui, T, Amici, DR, Giacomelli, AO, Rios, P, Butty, VL, Hahn, WC et al.. 2026. Mol Cell 86, 345-361.e6.
doi: 10.1016/j.molcel.2025.12.013PMID:41539306 - Nutrient requirements of organ-specific metastasis in breast cancer. Abbott, KL, Subudhi, S, Ferreira, R, Gültekin, Y, Steinbuch, SC, Munim, MB, Ramesh, DL, Honeder, SE, Kumar, AS, Wu, M et al.. 2026. Nature 649, 1292-1301.
doi: 10.1038/s41586-025-09898-9PMID:41501456 - CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency. Bucher, P, Brückner, N, Kortendieck, J, Grimm, M, Schleicher, JT, Bartels, K, Hardy, S, Rausch, M, Wurzer, H, Thiemann, M et al.. 2026. Nat Cancer 7, 368-383.
doi: 10.1038/s43018-025-01099-7PMID:41495526 - Publisher Correction: Computational prediction of human genetic variants in the mouse genome. Dong, K, Gould, SI, Li, M, Sánchez Rivera, FJ. 2025. Nat Biotechnol , .
doi: 10.1038/s41587-025-02991-4PMID:41466062 - Computational prediction of human genetic variants in the mouse genome. Dong, K, Gould, SI, Li, M, Sánchez Rivera, FJ. 2025. Nat Biotechnol , .
doi: 10.1038/s41587-025-02925-0PMID:41413243 - Mutant p53: evolving perspectives. Efe, G, Cunningham, K, Rustgi, AK, Prives, C, Manfredi, JJ, Sánchez-Rivera, FJ. 2026. Genes Dev 40, 4-25.
doi: 10.1101/gad.353408.125PMID:41397879 - A functional map of CDK-drug interactions at single amino acid resolution. Gould, SI, Acosta, J, Bielo, LB, Jaboldinov, A, Johnson, GA, Contreras, ME, Wuest, AN, Brémont, E, Toure, MA, Xiang, Y et al.. 2025. bioRxiv , .
doi: 10.1101/2025.11.02.685764PMID:41279360
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