PhD 1979, University of Minnesota
The Lauffenburger laboratory emphasizes integration of experimental and mathematical/computational analysis approaches, toward development and validation of predictive models for physiologically-relevant behavior in terms of underlying molecular and molecular network properties. Our work has been recognized as providing contributions fostering the interface of bioengineering, quantitative cell biology, and systems biology. Our main focus has been on fundamental aspects of cell dysregulation, complemented by translational efforts in identifying and testing new therapeutic ideas. Applications addressed have chiefly resided in various types of cancer (including breast, colon, lung, and pancreatic cancers along with leukemias and lymphomas), inflammatory pathologies (such as endometriosis, Crohn's disease, colitis, rheumatoid arthritis, and Alzheimer's disease), and the immune system (mainly for vaccines against pathogens such as HIV, malaria, and tuberculosis). We have increasingly emphasized complex tissue contexts, including mouse models, human subjects, and tissue-engineered micro-physiological systems platforms in association with outstanding collaborators. From our laboratory have come more than 100 doctoral and postdoctoral trainees. Many hold faculty positions at academic institutions in the USA, Canada, and Europe; others have gone on to research positions in biotechnology and pharmaceutical companies; and others yet have moved into policy and government agency careers.
- American Academy of Arts and Sciences, Fellow, 2001
- John Simon Guggenheim Memorial Foundation, Guggenheim Fellowship, 1989
- Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation. Tape, CJ, Ling, S, Dimitriadi, M, McMahon, KM, Worboys, JD, Leong, HS, Norrie, IC, Miller, CJ, Poulogiannis, G, Lauffenburger, DA et al.. 2016. Cell 165, 1818.
doi: 10.1016/j.cell.2016.05.079PMID: 27315484
- Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance. Miller, MA, Oudin, MJ, Sullivan, RJ, Wang, SJ, Meyer, AS, Im, H, Frederick, DT, Tadros, J, Griffith, LG, Lee, H et al.. 2016. Cancer Discov 6, 382-99.
doi: 10.1158/2159-8290.CD-15-0933PMID: 26984351
- CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals. Arnold, KB, Szeto, GL, Alter, G, Irvine, DJ, Lauffenburger, DA. 2015. Sci Signal 8, ra104.
doi: 10.1126/scisignal.aab0808PMID: 26486173
- The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity. Meyer, AS, Zweemer, AJ, Lauffenburger, DA. 2015. Cell Syst 1, 25-36.
doi: 10.1016/j.cels.2015.06.002PMID: 26236777
- Intratumor heterogeneity alters most effective drugs in designed combinations. Zhao, B, Hemann, MT, Lauffenburger, DA. 2014. Proc. Natl. Acad. Sci. U.S.A. 111, 10773-8.
doi: 10.1073/pnas.1323934111PMID: 25002493
- Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies. Edington, CD, Chen, WLK, Geishecker, E, Kassis, T, Soenksen, LR, Bhushan, BM, Freake, D, Kirschner, J, Maass, C, Tsamandouras, N et al.. 2018. Sci Rep 8, 4530.
doi: 10.1038/s41598-018-22749-0PMID: 29540740
- Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition. Jones, DS, Jenney, AP, Joughin, BA, Sorger, PK, Lauffenburger, DA. 2018. Sci Signal 11, .
doi: 10.1126/scisignal.aal1601PMID: 29511118
- In vivo systems biology approaches to chronic immune/inflammatory pathophysiology. Starchenko, A, Lauffenburger, DA. 2018. Curr. Opin. Biotechnol. 52, 9-16.
doi: 10.1016/j.copbio.2018.02.006PMID: 29494996
- Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis. Lyons, J, Brubaker, DK, Ghazi, PC, Baldwin, KR, Edwards, A, Boukhali, M, Strasser, SD, Suarez-Lopez, L, Lin, YJ, Yajnik, V et al.. 2018. Sci Signal 11, .
doi: 10.1126/scisignal.aan3580PMID: 29487189
- Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis. Fleury, M, Belkina, AC, Proctor, EA, Zammitti, C, Simms, RW, Lauffenburger, DA, Snyder-Cappione, JE, Lafyatis, R, Dooms, H. 2017. , .
doi: 10.1002/art.40399PMID: 29245183
- Hepatic Dysfunction Caused by Consumption of a High-Fat Diet. Soltis, AR, Kennedy, NJ, Xin, X, Zhou, F, Ficarro, SB, Yap, YS, Matthews, BJ, Lauffenburger, DA, White, FM, Marto, JA et al.. 2017. Cell Rep 21, 3317-3328.
doi: 10.1016/j.celrep.2017.11.059PMID: 29241556
- Temporal variation in HIV-specific IgG subclass antibodies during acute infection differentiates spontaneous controllers from chronic progressors. Sadanand, S, Das, J, Chung, AW, Schoen, MK, Lane, S, Suscovich, TJ, Streeck, H, Smith, DM, Little, SJ, Lauffenburger, DA et al.. 2018. AIDS 32, 443-450.
doi: 10.1097/QAD.0000000000001716PMID: 29239894
- Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates. Yoneyama, T, Gorry, M, Miller, MA, Gaither-Davis, A, Lin, Y, Moss, ML, Griffith, LG, Lauffenburger, DA, Stabile, LP, Herman, JG et al.. 2017. J Cancer 8, 3916-3932.
doi: 10.7150/jca.20779PMID: 29187866
- Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding. Wilson, JL, Kefaloyianni, E, Stopfer, L, Harrison, C, Sabbisetti, VS, Fraenkel, E, Lauffenburger, DA, Herrlich, A. 2018. Mol. Cancer Res. 16, 147-161.
doi: 10.1158/1541-7786.MCR-17-0140PMID: 29018056
- Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells. Zweemer, AJM, French, CB, Mesfin, J, Gordonov, S, Meyer, AS, Lauffenburger, DA. 2017. Mol. Cancer Res. 15, 1656-1666.
doi: 10.1158/1541-7786.MCR-17-0012PMID: 28923840
Photo credit: Kathy Wittman