Education
- PhD, 1979, University of Minnesota
- BS, 1975, Chemical Engineering, University of Illinois, Urbana-Champaign
Research Summary
The Lauffenburger laboratory emphasizes integration of experimental and mathematical/computational analysis approaches, toward development and validation of predictive models for physiologically-relevant behavior in terms of underlying molecular and molecular network properties. Our work has been recognized as providing contributions fostering the interface of bioengineering, quantitative cell biology, and systems biology. Our main focus has been on fundamental aspects of cell dysregulation, complemented by translational efforts in identifying and testing new therapeutic ideas. Applications addressed have chiefly resided in various types of cancer (including breast, colon, lung, and pancreatic cancers along with leukemias and lymphomas), inflammatory pathologies (such as endometriosis, Crohn's disease, colitis, rheumatoid arthritis, and Alzheimer's disease), and the immune system (mainly for vaccines against pathogens such as HIV, malaria, and tuberculosis). We have increasingly emphasized complex tissue contexts, including mouse models, human subjects, and tissue-engineered micro-physiological systems platforms in association with outstanding collaborators. From our laboratory have come more than 100 doctoral and postdoctoral trainees. Many hold faculty positions at academic institutions in the USA, Canada, and Europe; others have gone on to research positions in biotechnology and pharmaceutical companies; and others yet have moved into policy and government agency careers.
Awards
- American Academy of Arts and Sciences, Fellow, 2001
- John Simon Guggenheim Memorial Foundation, Guggenheim Fellowship, 1989
Key Publications
- Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation. Tape, CJ, Ling, S, Dimitriadi, M, McMahon, KM, Worboys, JD, Leong, HS, Norrie, IC, Miller, CJ, Poulogiannis, G, Lauffenburger, DA et al.. 2016. Cell 165, 1818.
doi: 10.1016/j.cell.2016.05.079PMID:27315484 - Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance. Miller, MA, Oudin, MJ, Sullivan, RJ, Wang, SJ, Meyer, AS, Im, H, Frederick, DT, Tadros, J, Griffith, LG, Lee, H et al.. 2016. Cancer Discov 6, 382-99.
doi: 10.1158/2159-8290.CD-15-0933PMID:26984351 - CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals. Arnold, KB, Szeto, GL, Alter, G, Irvine, DJ, Lauffenburger, DA. 2015. Sci Signal 8, ra104.
doi: 10.1126/scisignal.aab0808PMID:26486173 - The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity. Meyer, AS, Zweemer, AJ, Lauffenburger, DA. 2015. Cell Syst 1, 25-36.
doi: 10.1016/j.cels.2015.06.002PMID:26236777 - Intratumor heterogeneity alters most effective drugs in designed combinations. Zhao, B, Hemann, MT, Lauffenburger, DA. 2014. Proc. Natl. Acad. Sci. U.S.A. 111, 10773-8.
doi: 10.1073/pnas.1323934111PMID:25002493
Recent Publications
- Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes. Nicholas, DA, Proctor, EA, Agrawal, M, Belkina, AC, Van Nostrand, SC, Panneerseelan-Bharath, L, Jones, AR 4th, Raval, F, Ip, BC, Zhu, M et al.. 2019. Cell Metab. , .
doi: 10.1016/j.cmet.2019.07.004PMID:31378464 - Author Correction: A systems biology pipeline identifies regulatory networks for stem cell engineering. Kinney, MA, Vo, LT, Frame, JM, Barragan, J, Conway, AJ, Li, S, Wong, KK, Collins, JJ, Cahan, P, North, TE et al.. 2019. Nat. Biotechnol. 37, 962.
doi: 10.1038/s41587-019-0212-1PMID:31312048 - VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells. Patterson, JC, Joughin, BA, Prota, AE, Mühlethaler, T, Jonas, OH, Whitman, MA, Varmeh, S, Chen, S, Balk, SP, Steinmetz, MO et al.. 2019. Cell Syst 9, 74-92.e8.
doi: 10.1016/j.cels.2019.05.009PMID:31302152 - A systems biology pipeline identifies regulatory networks for stem cell engineering. Kinney, MA, Vo, LT, Frame, JM, Barragan, J, Conway, AJ, Li, S, Wong, KK, Collins, JJ, Cahan, P, North, TE et al.. 2019. Nat. Biotechnol. 37, 810-818.
doi: 10.1038/s41587-019-0159-2PMID:31267104 - Small-molecule control of antibody N-glycosylation in engineered mammalian cells. Chang, MM, Gaidukov, L, Jung, G, Tseng, WA, Scarcelli, JJ, Cornell, R, Marshall, JK, Lyles, JL, Sakorafas, P, Chu, AA et al.. 2019. Nat. Chem. Biol. 15, 730-736.
doi: 10.1038/s41589-019-0288-4PMID:31110306 - Tissue-Specific Oncogenic Activity of KRASA146T. Poulin, EJ, Bera, AK, Lu, J, Lin, YJ, Strasser, SD, Paulo, JA, Huang, TQ, Morales, C, Yan, W, Cook, J et al.. 2019. Cancer Discov 9, 738-755.
doi: 10.1158/2159-8290.CD-18-1220PMID:30952657 - ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest. Patterson, JC, Joughin, BA, van de Kooij, B, Lim, DC, Lauffenburger, DA, Yaffe, MB. 2019. Cell Syst 8, 163-167.e2.
doi: 10.1016/j.cels.2019.01.005PMID:30797774 - Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes. Rohani, N, Hao, L, Alexis, MS, Joughin, BA, Krismer, K, Moufarrej, MN, Soltis, AR, Lauffenburger, DA, Yaffe, MB, Burge, CB et al.. 2019. Cancer Res. 79, 1952-1966.
doi: 10.1158/0008-5472.CAN-18-1604PMID:30755444 - Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses. Sumit, M, Dolatshahi, S, Chu, AA, Cote, K, Scarcelli, JJ, Marshall, JK, Cornell, RJ, Weiss, R, Lauffenburger, DA, Mulukutla, BC et al.. 2019. iScience 12, 102-120.
doi: 10.1016/j.isci.2019.01.006PMID:30682623 - Computational translation of genomic responses from experimental model systems to humans. Brubaker, DK, Proctor, EA, Haigis, KM, Lauffenburger, DA. 2019. PLoS Comput. Biol. 15, e1006286.
doi: 10.1371/journal.pcbi.1006286PMID:30629591
Photo credit: Kathy Wittman
