Education
- PhD, 1979, University of Minnesota
- BS, 1975, Chemical Engineering, University of Illinois, Urbana-Champaign
Research Summary
The Lauffenburger laboratory emphasizes integration of experimental and mathematical/computational analysis approaches, toward development and validation of predictive models for physiologically-relevant behavior in terms of underlying molecular and molecular network properties. Our work has been recognized as providing contributions fostering the interface of bioengineering, quantitative cell biology, and systems biology. Our main focus has been on fundamental aspects of cell dysregulation, complemented by translational efforts in identifying and testing new therapeutic ideas. Applications addressed have chiefly resided in various types of cancer (including breast, colon, lung, and pancreatic cancers along with leukemias and lymphomas), inflammatory pathologies (such as endometriosis, Crohn's disease, colitis, rheumatoid arthritis, and Alzheimer's disease), and the immune system (mainly for vaccines against pathogens such as HIV, malaria, and tuberculosis). We have increasingly emphasized complex tissue contexts, including mouse models, human subjects, and tissue-engineered micro-physiological systems platforms in association with outstanding collaborators. From our laboratory have come more than 100 doctoral and postdoctoral trainees. Many hold faculty positions at academic institutions in the USA, Canada, and Europe; others have gone on to research positions in biotechnology and pharmaceutical companies; and others yet have moved into policy and government agency careers.
Awards
- Bernard M. Gordon Prize for Innovation in Engineering and Technology Education, National Academy of Engineering, 2021
- American Association for the Advancement of Science, Member, 2019
- American Academy of Arts and Sciences, Fellow, 2001
- John Simon Guggenheim Memorial Foundation, Guggenheim Fellowship, 1989
Recent Publications
- Axl inhibitor-mediated reprogramming of the myeloid compartment of the in vitro tumor microenvironment is influenced by prior targeted therapy treatment. Datta, A, Bahlmann, LC, Gong, DN, Tevonian, EN, Lorens, JB, Lauffenburger, DA. 2025. Front Immunol 16, 1601420.
doi: 10.3389/fimmu.2025.1601420PMID:40539073 - Library-based single-cell analysis of CAR signaling reveals drivers of in vivo persistence. Perez, CR, Garmilla, A, Nilsson, A, Baghdassarian, HM, Gordon, KS, Lima, LG, Smith, BE, Maus, MV, Lauffenburger, DA, Birnbaum, ME et al.. 2025. Cell Syst 16, 101260.
doi: 10.1016/j.cels.2025.101260PMID:40215972 - Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans. Proulx, MK, Wiggins, CD, Reames, CJ, Wu, C, Kiritsy, MC, Xu, P, Gallant, JC, Grace, PS, Fenderson, BA, Smith, CM et al.. 2025. J Exp Med 222, .
doi: 10.1084/jem.20241760PMID:40192640 - Cross-species transcriptomics translation reveals a role for the unfolded protein response in Mycobacterium tuberculosis infection. Pullen, KM, Finethy, R, Ko, SB, Reames, CJ, Sassetti, CM, Lauffenburger, DA. 2025. NPJ Syst Biol Appl 11, 19.
doi: 10.1038/s41540-024-00487-6PMID:39955299 - Combinatorial Fc modifications for complementary antibody functionality. Bartsch, YC, Webb, NE, Burgess, E, Kang, J, Lauffenburger, DA, Julg, BD. 2025. MAbs 17, 2465391.
doi: 10.1080/19420862.2025.2465391PMID:39950649 - Towards an interpretable deep learning model of cancer. Nilsson, A, Meimetis, N, Lauffenburger, DA. 2025. NPJ Precis Oncol 9, 46.
doi: 10.1038/s41698-025-00822-yPMID:39948231 - Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma. Gordon, KS, Perez, CR, Garmilla, A, Lam, MSY, Aw, JJY, Datta, A, Lauffenburger, DA, Pavesi, A, Birnbaum, ME. 2025. J Immunother Cancer 13, .
doi: 10.1136/jitc-2024-009574PMID:39933837 - Protocol to infer off-target effects of drugs on cellular signaling using interactome-based deep learning. Meimetis, N, Lauffenburger, DA, Nilsson, A. 2025. STAR Protoc 6, 103573.
doi: 10.1016/j.xpro.2024.103573PMID:39823233 - Author Correction: AutoTransOP: translating omics signatures without orthologue requirements using deep learning. Meimetis, N, Pullen, KM, Zhu, DY, Nilsson, A, Hoang, TN, Magliacane, S, Lauffenburger, DA. 2024. NPJ Syst Biol Appl 10, 148.
doi: 10.1038/s41540-024-00456-zPMID:39672816 - Humoral correlates of protection against Mycobacterium tuberculosis following intravenous BCG vaccination in rhesus macaques. Irvine, EB, Darrah, PA, Wang, S, Wang, C, McNamara, RP, Roederer, M, Seder, RA, Lauffenburger, DA, Flynn, JL, Fortune, SM et al.. 2024. iScience 27, 111128.
doi: 10.1016/j.isci.2024.111128PMID:39669431
