David Bartel

David Bartel

Professor of Biology; Member, Whitehead Institute; Investigator, Howard Hughes Medical Institute

David Bartel studies molecular pathways that regulate eukaryotic gene expression by affecting the stability or translation of mRNAs.

617-258-5287

Phone

WI-601B

Office

Laura Resteghini

Assistant

617-258-7778

Assistant Phone

Education

PhD 1993, Harvard University

Research Summary

We study microRNAs and other small RNAs that specify the destruction and/or translational repression of mRNAs. We also study mRNAs, focusing on their untranslated regions and poly(A) tails, and how these regions recruit and mediate regulatory phenomena.

Awards

  • National Academy of Sciences, Member, 2011
  • Howard Hughes Medical Institute, HHMI Investigator, 2005
  • National Academy of Sciences Award in Molecular Biology, 2005
  • AAAS Newcomb Cleveland Prize, 2002

Recent Publications

  1. The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs. Guenther, UP, Weinberg, DE, Zubradt, MM, Tedeschi, FA, Stawicki, BN, Zagore, LL, Brar, GA, Licatalosi, DD, Bartel, DP, Weissman, JS et al.. 2018. Nature 559, 130-134.
    doi: 10.1038/s41586-018-0258-0PMID:29950728
  2. A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain. Kleaveland, B, Shi, CY, Stefano, J, Bartel, DP. 2018. Cell 174, 350-362.e17.
    doi: 10.1016/j.cell.2018.05.022PMID:29887379
  3. New CRISPR Mutagenesis Strategies Reveal Variation in Repair Mechanisms among Fungi. Vyas, VK, Bushkin, GG, Bernstein, DA, Getz, MA, Sewastianik, M, Barrasa, MI, Bartel, DP, Fink, GR. 2018. mSphere 3, .
    doi: 10.1128/mSphere.00154-18PMID:29695624
  4. Metazoan MicroRNAs. Bartel, DP. 2018. Cell 173, 20-51.
    doi: 10.1016/j.cell.2018.03.006PMID:29570994
  5. A Seed Mismatch Enhances Argonaute2-Catalyzed Cleavage and Partially Rescues Severely Impaired Cleavage Found in Fish. Chen, GR, Sive, H, Bartel, DP. 2017. Mol. Cell 68, 1095-1107.e5.
    doi: 10.1016/j.molcel.2017.11.032PMID:29272705
  6. The influence of microRNAs and poly(A) tail length on endogenous mRNA-protein complexes. Rissland, OS, Subtelny, AO, Wang, M, Lugowski, A, Nicholson, B, Laver, JD, Sidhu, SS, Smibert, CA, Lipshitz, HD, Bartel, DP. 2017. Genome Biol. 18, 211.
    doi: 10.1186/s13059-017-1330-zPMID:29089021
  7. Widespread Influence of 3'-End Structures on Mammalian mRNA Processing and Stability. Wu, X, Bartel, DP. 2017. Cell 169, 905-917.e11.
    doi: 10.1016/j.cell.2017.04.036PMID:28525757
  8. kpLogo: positional k-mer analysis reveals hidden specificity in biological sequences. Wu, X, Bartel, DP. 2017. Nucleic Acids Res. 45, W534-W538.
    doi: 10.1093/nar/gkx323PMID:28460012
  9. Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways. Khurana, V, Peng, J, Chung, CY, Auluck, PK, Fanning, S, Tardiff, DF, Bartels, T, Koeva, M, Eichhorn, SW, Benyamini, H et al.. 2017. Cell Syst 4, 157-170.e14.
    doi: 10.1016/j.cels.2016.12.011PMID:28131822
  10. Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression. Denzler, R, McGeary, SE, Title, AC, Agarwal, V, Bartel, DP, Stoffel, M. 2016. Mol. Cell 64, 565-579.
    doi: 10.1016/j.molcel.2016.09.027PMID:27871486
More Publications

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Photo credit: Gretchen Ertl/Whitehead Institute