David Bartel

David Bartel

Professor of Biology; Member, Whitehead Institute; Investigator, Howard Hughes Medical Institute

David Bartel studies molecular pathways that regulate eukaryotic gene expression by affecting the stability or translation of mRNAs.





Laura Resteghini



Assistant Phone


  • PhD, 1993, Harvard University
  • BA, 1982, Biology, Goshen College

Research Summary

We study microRNAs and other small RNAs that specify the destruction and/or translational repression of mRNAs. We also study mRNAs, focusing on their untranslated regions and poly(A) tails, and how these regions recruit and mediate regulatory phenomena.


  • National Academy of Sciences, Member, 2011
  • Howard Hughes Medical Institute, HHMI Investigator, 2005
  • National Academy of Sciences Award in Molecular Biology, 2005
  • AAAS Newcomb Cleveland Prize, 2002

Recent Publications

  1. The Dynamics of Cytoplasmic mRNA Metabolism. Eisen, TJ, Eichhorn, SW, Subtelny, AO, Lin, KS, McGeary, SE, Gupta, S, Bartel, DP. 2019. Mol. Cell , .
    doi: 10.1016/j.molcel.2019.12.005PMID:31902669
  2. MicroRNAs Cause Accelerated Decay of Short-Tailed Target mRNAs. Eisen, TJ, Eichhorn, SW, Subtelny, AO, Bartel, DP. 2019. Mol. Cell , .
    doi: 10.1016/j.molcel.2019.12.004PMID:31902668
  3. The biochemical basis of microRNA targeting efficacy. McGeary, SE, Lin, KS, Shi, CY, Pham, TM, Bisaria, N, Kelley, GM, Bartel, DP. 2019. Science 366, .
    doi: 10.1126/science.aav1741PMID:31806698
  4. Global analyses of the dynamics of mammalian microRNA metabolism. Kingston, ER, Bartel, DP. 2019. Genome Res. 29, 1777-1790.
    doi: 10.1101/gr.251421.119PMID:31519739
  5. m6A modification of a 3' UTR site reduces RME1 mRNA levels to promote meiosis. Bushkin, GG, Pincus, D, Morgan, JT, Richardson, K, Lewis, C, Chan, SH, Bartel, DP, Fink, GR. 2019. Nat Commun 10, 3414.
    doi: 10.1038/s41467-019-11232-7PMID:31363087
  6. Early genome activation in Drosophila is extensive with an initial tendency for aborted transcripts and retained introns. Kwasnieski, JC, Orr-Weaver, TL, Bartel, DP. 2019. Genome Res. 29, 1188-1197.
    doi: 10.1101/gr.242164.118PMID:31235656
  7. Excised linear introns regulate growth in yeast. Morgan, JT, Fink, GR, Bartel, DP. 2019. Nature 565, 606-611.
    doi: 10.1038/s41586-018-0828-1PMID:30651636
  8. Genetic dissection of the miR-200-Zeb1 axis reveals its importance in tumor differentiation and invasion. Title, AC, Hong, SJ, Pires, ND, Hasenöhrl, L, Godbersen, S, Stokar-Regenscheit, N, Bartel, DP, Stoffel, M. 2018. Nat Commun 9, 4671.
    doi: 10.1038/s41467-018-07130-zPMID:30405106
  9. Predicting microRNA targeting efficacy in Drosophila. Agarwal, V, Subtelny, AO, Thiru, P, Ulitsky, I, Bartel, DP. 2018. Genome Biol. 19, 152.
    doi: 10.1186/s13059-018-1504-3PMID:30286781
  10. The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs. Guenther, UP, Weinberg, DE, Zubradt, MM, Tedeschi, FA, Stawicki, BN, Zagore, LL, Brar, GA, Licatalosi, DD, Bartel, DP, Weissman, JS et al.. 2018. Nature 559, 130-134.
    doi: 10.1038/s41586-018-0258-0PMID:29950728
More Publications




Photo credit: Gretchen Ertl/Whitehead Institute