Education
- PhD, 1993, Harvard University
- BA, 1982, Biology, Goshen College
Research Summary
We study microRNAs and other small RNAs that specify the destruction and/or translational repression of mRNAs. We also study mRNAs, focusing on their untranslated regions and poly(A) tails, and how these regions recruit and mediate regulatory phenomena.Awards
- National Academy of Sciences, Member, 2011
- Howard Hughes Medical Institute, HHMI Investigator, 2005
- National Academy of Sciences Award in Molecular Biology, 2005
- AAAS Newcomb Cleveland Prize, 2002
Key Publications
- The molecular basis of coupling between poly(A)-tail length and translational efficiency. Xiang, K, Bartel, DP. 2021. Elife 10, .
doi: 10.7554/eLife.66493PMID:34213414 - The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation. Shi, CY, Kingston, ER, Kleaveland, B, Lin, DH, Stubna, MW, Bartel, DP. 2020. Science 370, .
doi: 10.1126/science.abc9359PMID:33184237 - The biochemical basis of microRNA targeting efficacy. McGeary, SE, Lin, KS, Shi, CY, Pham, TM, Bisaria, N, Kelley, GM, Bartel, DP. 2019. Science 366, .
doi: 10.1126/science.aav1741PMID:31806698 - Excised linear introns regulate growth in yeast. Morgan, JT, Fink, GR, Bartel, DP. 2019. Nature 565, 606-611.
doi: 10.1038/s41586-018-0828-1PMID:30651636 - A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain. Kleaveland, B, Shi, CY, Stefano, J, Bartel, DP. 2018. Cell 174, 350-362.e17.
doi: 10.1016/j.cell.2018.05.022PMID:29887379
Recent Publications
- ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development. Shi, CY, Elcavage, LE, Chivukula, RR, Stefano, J, Kleaveland, B, Bartel, DP. 2023. Genome Res , .
doi: 10.1101/gr.278073.123PMID:37532519 - A statistical approach for identifying primary substrates of ZSWIM8-mediated microRNA degradation in small-RNA sequencing data. Wang, PY, Bartel, DP. 2023. BMC Bioinformatics 24, 195.
doi: 10.1186/s12859-023-05306-zPMID:37170259 - Endogenous transcripts direct microRNA degradation in Drosophila, and this targeted degradation is required for proper embryonic development. Kingston, ER, Blodgett, LW, Bartel, DP. 2022. Mol Cell 82, 3872-3884.e9.
doi: 10.1016/j.molcel.2022.08.029PMID:36150386 - The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability. Hallacli, E, Kayatekin, C, Nazeen, S, Wang, XH, Sheinkopf, Z, Sathyakumar, S, Sarkar, S, Jiang, X, Dong, X, Di Maio, R et al.. 2022. Cell 185, 2035-2056.e33.
doi: 10.1016/j.cell.2022.05.008PMID:35688132 - The interplay between translational efficiency, poly(A) tails, microRNAs, and neuronal activation. Eisen, TJ, Li, JJ, Bartel, DP. 2022. RNA 28, 808-831.
doi: 10.1261/rna.079046.121PMID:35273099 - MicroRNA 3'-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position. McGeary, SE, Bisaria, N, Pham, TM, Wang, PY, Bartel, DP. 2022. Elife 11, .
doi: 10.7554/eLife.69803PMID:35191832 - Corrigendum: Ago2 protects Drosophila siRNAs and microRNAs from target-directed degradation, even in the absence of 2'-O-methylation. Kingston, ER, Bartel, DP. 2021. RNA 27, 1617.
doi: 10.1261/rna.078961.121PMID:34785574 - The molecular basis of coupling between poly(A)-tail length and translational efficiency. Xiang, K, Bartel, DP. 2021. Elife 10, .
doi: 10.7554/eLife.66493PMID:34213414 - Degradation of host translational machinery drives tRNA acquisition in viruses. Yang, JY, Fang, W, Miranda-Sanchez, F, Brown, JM, Kauffman, KM, Acevero, CM, Bartel, DP, Polz, MF, Kelly, L. 2021. Cell Syst 12, 771-779.e5.
doi: 10.1016/j.cels.2021.05.019PMID:34143976 - Ago2 protects Drosophila siRNAs and microRNAs from target-directed degradation, even in the absence of 2'-O-methylation. Kingston, ER, Bartel, DP. 2021. RNA 27, 710-724.
doi: 10.1261/rna.078746.121PMID:33853897
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