David Bartel

David Bartel

Professor of Biology; Member, Whitehead Institute; Investigator, Howard Hughes Medical Institute

David Bartel studies molecular pathways that regulate eukaryotic gene expression by affecting the stability or translation of mRNAs.

617-258-5287

Phone

WI-601B

Office

Laura Resteghini

Assistant

617-258-7778

Assistant Phone

Education

  • PhD, 1993, Harvard University
  • BA, 1982, Biology, Goshen College

Research Summary

We study microRNAs and other small RNAs that specify the destruction and/or translational repression of mRNAs. We also study mRNAs, focusing on their untranslated regions and poly(A) tails, and how these regions recruit and mediate regulatory phenomena.

Awards

  • National Academy of Sciences, Member, 2011
  • Howard Hughes Medical Institute, HHMI Investigator, 2005
  • National Academy of Sciences Award in Molecular Biology, 2005
  • AAAS Newcomb Cleveland Prize, 2002

Key Publications

  1. The biochemical basis of microRNA targeting efficacy. McGeary, SE, Lin, KS, Shi, CY, Pham, TM, Bisaria, N, Kelley, GM, Bartel, DP. 2019. Science 366, .
    doi: 10.1126/science.aav1741PMID:31806698
  2. Excised linear introns regulate growth in yeast. Morgan, JT, Fink, GR, Bartel, DP. 2019. Nature 565, 606-611.
    doi: 10.1038/s41586-018-0828-1PMID:30651636
  3. A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain. Kleaveland, B, Shi, CY, Stefano, J, Bartel, DP. 2018. Cell 174, 350-362.e17.
    doi: 10.1016/j.cell.2018.05.022PMID:29887379
  4. Widespread Influence of 3'-End Structures on Mammalian mRNA Processing and Stability. Wu, X, Bartel, DP. 2017. Cell 169, 905-917.e11.
    doi: 10.1016/j.cell.2017.04.036PMID:28525757
  5. RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria. Guo, JU, Bartel, DP. 2016. Science 353, .
    doi: 10.1126/science.aaf5371PMID:27708011

Recent Publications

  1. The biochemical basis for the cooperative action of microRNAs. Briskin, D, Wang, PY, Bartel, DP. 2020. Proc. Natl. Acad. Sci. U.S.A. 117, 17764-17774.
    doi: 10.1073/pnas.1920404117PMID:32661162
  2. Xrn1p acts at multiple steps in the budding-yeast RNAi pathway to enhance the efficiency of silencing. Getz, MA, Weinberg, DE, Drinnenberg, IA, Fink, GR, Bartel, DP. 2020. Nucleic Acids Res. 48, 7404-7420.
    doi: 10.1093/nar/gkaa468PMID:32501509
  3. MicroRNA Clustering Assists Processing of Suboptimal MicroRNA Hairpins through the Action of the ERH Protein. Fang, W, Bartel, DP. 2020. Mol. Cell 78, 289-302.e6.
    doi: 10.1016/j.molcel.2020.01.026PMID:32302541
  4. The Dynamics of Cytoplasmic mRNA Metabolism. Eisen, TJ, Eichhorn, SW, Subtelny, AO, Lin, KS, McGeary, SE, Gupta, S, Bartel, DP. 2020. Mol. Cell 77, 786-799.e10.
    doi: 10.1016/j.molcel.2019.12.005PMID:31902669
  5. MicroRNAs Cause Accelerated Decay of Short-Tailed Target mRNAs. Eisen, TJ, Eichhorn, SW, Subtelny, AO, Bartel, DP. 2020. Mol. Cell 77, 775-785.e8.
    doi: 10.1016/j.molcel.2019.12.004PMID:31902668
  6. The biochemical basis of microRNA targeting efficacy. McGeary, SE, Lin, KS, Shi, CY, Pham, TM, Bisaria, N, Kelley, GM, Bartel, DP. 2019. Science 366, .
    doi: 10.1126/science.aav1741PMID:31806698
  7. Global analyses of the dynamics of mammalian microRNA metabolism. Kingston, ER, Bartel, DP. 2019. Genome Res. 29, 1777-1790.
    doi: 10.1101/gr.251421.119PMID:31519739
  8. m6A modification of a 3' UTR site reduces RME1 mRNA levels to promote meiosis. Bushkin, GG, Pincus, D, Morgan, JT, Richardson, K, Lewis, C, Chan, SH, Bartel, DP, Fink, GR. 2019. Nat Commun 10, 3414.
    doi: 10.1038/s41467-019-11232-7PMID:31363087
  9. Early genome activation in Drosophila is extensive with an initial tendency for aborted transcripts and retained introns. Kwasnieski, JC, Orr-Weaver, TL, Bartel, DP. 2019. Genome Res. 29, 1188-1197.
    doi: 10.1101/gr.242164.118PMID:31235656
  10. Excised linear introns regulate growth in yeast. Morgan, JT, Fink, GR, Bartel, DP. 2019. Nature 565, 606-611.
    doi: 10.1038/s41586-018-0828-1PMID:30651636
More Publications

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Photo credit: Gretchen Ertl/Whitehead Institute