Education
- PhD, 1993, Harvard University
- BA, 1982, Biology, Goshen College
Research Summary
We study microRNAs and other small RNAs that specify the destruction and/or translational repression of mRNAs. We also study mRNAs, focusing on their untranslated regions and poly(A) tails, and how these regions recruit and mediate regulatory phenomena.Awards
- National Academy of Sciences, Member, 2011
- Howard Hughes Medical Institute, HHMI Investigator, 2005
- National Academy of Sciences Award in Molecular Biology, 2005
- AAAS Newcomb Cleveland Prize, 2002
Key Publications
Recent Publications
- The structural basis for RNA slicing by human Argonaute2. Mohamed, AA, Wang, PY, Bartel, DP, Vos, SM. 2025. Cell Rep 44, 115166.
doi: 10.1016/j.celrep.2024.115166PMID:39932188 - Nuclear release of eIF1 restricts start-codon selection during mitosis. Ly, J, Xiang, K, Su, KC, Sissoko, GB, Bartel, DP, Cheeseman, IM. 2024. Nature 635, 490-498.
doi: 10.1038/s41586-024-08088-3PMID:39443796 - Widespread destabilization of Caenorhabditis elegans microRNAs by the E3 ubiquitin ligase EBAX-1. Stubna, MW, Shukla, A, Bartel, DP. 2024. RNA 31, 51-66.
doi: 10.1261/rna.080276.124PMID:39433399 - The structural basis for RNA slicing by human Argonaute2. Mohamed, AA, Wang, PY, Bartel, DP, Vos, SM. 2024. bioRxiv , .
doi: 10.1101/2024.08.19.608718PMID:39229170 - The guide-RNA sequence dictates the slicing kinetics and conformational dynamics of the Argonaute silencing complex. Wang, PY, Bartel, DP. 2024. Mol Cell 84, 2918-2934.e11.
doi: 10.1016/j.molcel.2024.06.026PMID:39025072 - The guide RNA sequence dictates the slicing kinetics and conformational dynamics of the Argonaute silencing complex. Wang, PY, Bartel, DP. 2024. bioRxiv , .
doi: 10.1101/2023.10.15.562437PMID:38766062 - Nuclear release of eIF1 globally increases stringency of start-codon selection to preserve mitotic arrest physiology. Ly, J, Xiang, K, Su, KC, Sissoko, GB, Bartel, DP, Cheeseman, IM. 2024. bioRxiv , .
doi: 10.1101/2024.04.06.588385PMID:38617206 - Control of poly(A)-tail length and translation in vertebrate oocytes and early embryos. Xiang, K, Ly, J, Bartel, DP. 2024. Dev Cell 59, 1058-1074.e11.
doi: 10.1016/j.devcel.2024.02.007PMID:38460509 - ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development. Shi, CY, Elcavage, LE, Chivukula, RR, Stefano, J, Kleaveland, B, Bartel, DP. 2023. Genome Res 33, 1482-1496.
doi: 10.1101/gr.278073.123PMID:37532519 - A statistical approach for identifying primary substrates of ZSWIM8-mediated microRNA degradation in small-RNA sequencing data. Wang, PY, Bartel, DP. 2023. BMC Bioinformatics 24, 195.
doi: 10.1186/s12859-023-05306-zPMID:37170259
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