Bruce Walker

Bruce Walker

Professor of the Practice

Bruce Walker investigates cellular immune responses in chronic human viral infections, with a particular focus on HIV immunology and vaccine development.

857-268-7073

Phone

Ragon Institute, Room 870 (400 Technology Square)

Office

Marissa Ferrara

Assistant

857-268-7073

Assistant Phone

Education

  • PhD, 1993, University of Vienna
  • BS, 1989, Biology, University of Vienna

Research Summary

The overarching goal of my laboratory is to define the interplay of immunologic, virologic and host genetic factors that determine control of human viral infections, to guide vaccine development and immunotherapeutic interventions. To address this goal, we focus on HIV infection.

Awards

  • ​Bernard Fields Lectureship, 2015
  • NIH Merit Award, 2011, 2004
  • American Academy of Arts and Sciences, 2010
  • National Academy of Medicine, 2009
  • American Association of Physicians, 2000
  • Doris Duke Charitable Foundation Distinguished Clinical Scientist Award, 1999
  • American Society for Clinical Investigation, 1993

Key Publications

  1. Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection. Ndhlovu, ZM, Kazer, SW, Nkosi, T, Ogunshola, F, Muema, DM, Anmole, G, Swann, SA, Moodley, A, Dong, K, Reddy, T et al.. 2019. Sci Transl Med 11, .
    doi: 10.1126/scitranslmed.aau0528PMID:31118290
  2. Structural topology defines protective CD8+ T cell epitopes in the HIV proteome. Gaiha, GD, Rossin, EJ, Urbach, J, Landeros, C, Collins, DR, Nwonu, C, Muzhingi, I, Anahtar, MN, Waring, OM, Piechocka-Trocha, A et al.. 2019. Science 364, 480-484.
    doi: 10.1126/science.aav5095PMID:31048489
  3. Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system. Clayton, KL, Collins, DR, Lengieza, J, Ghebremichael, M, Dotiwala, F, Lieberman, J, Walker, BD. 2018. Nat Immunol 19, 475-486.
    doi: 10.1038/s41590-018-0085-3PMID:29670239
  4. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Park, RJ, Wang, T, Koundakjian, D, Hultquist, JF, Lamothe-Molina, P, Monel, B, Schumann, K, Yu, H, Krupzcak, KM, Garcia-Beltran, W et al.. 2017. Nat Genet 49, 193-203.
    doi: 10.1038/ng.3741PMID:27992415
  5. Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion. Ranasinghe, S, Lamothe, PA, Soghoian, DZ, Kazer, SW, Cole, MB, Shalek, AK, Yosef, N, Jones, RB, Donaghey, F, Nwonu, C et al.. 2016. Immunity 45, 917-930.
    doi: 10.1016/j.immuni.2016.09.015PMID:27760342
  6. Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. Ndhlovu, ZM, Kamya, P, Mewalal, N, Kløverpris, HN, Nkosi, T, Pretorius, K, Laher, F, Ogunshola, F, Chopera, D, Shekhar, K et al.. 2015. Immunity 43, 591-604.
    doi: 10.1016/j.immuni.2015.08.012PMID:26362266
  7. TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Chen, H, Ndhlovu, ZM, Liu, D, Porter, LC, Fang, JW, Darko, S, Brockman, MA, Miura, T, Brumme, ZL, Schneidewind, A et al.. 2012. Nat Immunol 13, 691-700.
    doi: 10.1038/ni.2342PMID:22683743
  8. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. International HIV Controllers Study, Pereyra, F, Jia, X, McLaren, PJ, Telenti, A, de Bakker, PI, Walker, BD, Ripke, S, Brumme, CJ, Pulit, SL et al.. 2010. Science 330, 1551-7.
    doi: 10.1126/science.1195271PMID:21051598
  9. CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Kiepiela, P, Ngumbela, K, Thobakgale, C, Ramduth, D, Honeyborne, I, Moodley, E, Reddy, S, de Pierres, C, Mncube, Z, Mkhwanazi, N et al.. 2007. Nat Med 13, 46-53.
    doi: 10.1038/nm1520PMID:17173051
  10. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Day, CL, Kaufmann, DE, Kiepiela, P, Brown, JA, Moodley, ES, Reddy, S, Mackey, EW, Miller, JD, Leslie, AJ, DePierres, C et al.. 2006. Nature 443, 350-4.
    doi: 10.1038/nature05115PMID:16921384

Recent Publications

  1. Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes. Garcia-Bates, TM, Palma, ML, Anderko, RR, Hsu, DC, Ananworanich, J, Korber, BT, Gaiha, GD, Phanuphak, N, Thomas, R, Tovanabutra, S et al.. 2021. EBioMedicine 63, 103175.
    doi: 10.1016/j.ebiom.2020.103175PMID:33450518
  2. A sealed-tube method for offline δ13 C analysis of CO2 via a Gas Bench II continuous flow isotope ratio mass spectrometer. Walker, BD, Beaupré, SR, Griffin, S, Walker, J, Druffel, E, Xu, X. 2020. Rapid Commun Mass Spectrom , .
    doi: 10.1002/rcm.9040PMID:33373477
  3. Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic. Edlow, AG, Li, JZ, Collier, AY, Atyeo, C, James, KE, Boatin, AA, Gray, KJ, Bordt, EA, Shook, LL, Yonker, LM et al.. 2020. JAMA Netw Open 3, e2030455.
    doi: 10.1001/jamanetworkopen.2020.30455PMID:33351086
  4. Profound Treg perturbations correlate with COVID-19 severity. Galván-Peña, S, Leon, J, Chowdhary, K, Michelson, DA, Vijaykumar, B, Yang, L, Magnuson, A, Manickas-Hill, Z, Piechocka-Trocha, A, Worrall, DP et al.. 2020. bioRxiv , .
    doi: 10.1101/2020.12.11.416180PMID:33330871
  5. Evolution and Diversity of Immune Responses during Acute HIV Infection. Kazer, SW, Walker, BD, Shalek, AK. 2020. Immunity 53, 908-924.
    doi: 10.1016/j.immuni.2020.10.015PMID:33207216
  6. Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host. Choi, B, Choudhary, MC, Regan, J, Sparks, JA, Padera, RF, Qiu, X, Solomon, IH, Kuo, HH, Boucau, J, Bowman, K et al.. 2020. N Engl J Med 383, 2291-2293.
    doi: 10.1056/NEJMc2031364PMID:33176080
  7. SARS-CoV-2 viral load is associated with increased disease severity and mortality. Fajnzylber, J, Regan, J, Coxen, K, Corry, H, Wong, C, Rosenthal, A, Worrall, D, Giguel, F, Piechocka-Trocha, A, Atyeo, C et al.. 2020. Nat Commun 11, 5493.
    doi: 10.1038/s41467-020-19057-5PMID:33127906
  8. Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. Shrock, E, Fujimura, E, Kula, T, Timms, RT, Lee, IH, Leng, Y, Robinson, ML, Sie, BM, Li, MZ, Chen, Y et al.. 2020. Science 370, .
    doi: 10.1126/science.abd4250PMID:32994364
  9. Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing. Joung, J, Ladha, A, Saito, M, Kim, NG, Woolley, AE, Segel, M, Barretto, RPJ, Ranu, A, Macrae, RK, Faure, G et al.. 2020. N Engl J Med 383, 1492-1494.
    doi: 10.1056/NEJMc2026172PMID:32937062
  10. Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes. Painter, MM, Zimmerman, GE, Merlino, MS, Robertson, AW, Terry, VH, Ren, X, McLeod, MR, Gomez-Rodriguez, L, Garcia, KA, Leonard, JA et al.. 2020. Proc Natl Acad Sci U S A 117, 23835-23846.
    doi: 10.1073/pnas.2008615117PMID:32900948
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Photo credit: Howard Hughes Medical Institute