Bruce Walker

Bruce Walker

Professor of the Practice

Bruce Walker investigates cellular immune responses in chronic human viral infections, with a particular focus on HIV immunology and vaccine development.

857-268-7073

Phone

Ragon Institute, Room 870 (400 Technology Square)

Office

Gabriella Berger

Assistant

857-268-7073

Assistant Phone

Education

  • PhD, 1993, University of Vienna
  • BS, 1989, Biology, University of Vienna

Research Summary

The overarching goal of my laboratory is to define the interplay of immunologic, virologic and host genetic factors that determine control of human viral infections, to guide vaccine development and immunotherapeutic interventions. To address this goal, we focus on HIV infection.

Awards

  • ​Bernard Fields Lectureship, 2015
  • NIH Merit Award, 2011, 2004
  • American Academy of Arts and Sciences, 2010
  • National Academy of Medicine, 2009
  • American Association of Physicians, 2000
  • Doris Duke Charitable Foundation Distinguished Clinical Scientist Award, 1999
  • American Society for Clinical Investigation, 1993

Key Publications

  1. Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection. Ndhlovu, ZM, Kazer, SW, Nkosi, T, Ogunshola, F, Muema, DM, Anmole, G, Swann, SA, Moodley, A, Dong, K, Reddy, T et al.. 2019. Sci Transl Med 11, .
    doi: 10.1126/scitranslmed.aau0528PMID:31118290
  2. Structural topology defines protective CD8+ T cell epitopes in the HIV proteome. Gaiha, GD, Rossin, EJ, Urbach, J, Landeros, C, Collins, DR, Nwonu, C, Muzhingi, I, Anahtar, MN, Waring, OM, Piechocka-Trocha, A et al.. 2019. Science 364, 480-484.
    doi: 10.1126/science.aav5095PMID:31048489
  3. Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system. Clayton, KL, Collins, DR, Lengieza, J, Ghebremichael, M, Dotiwala, F, Lieberman, J, Walker, BD. 2018. Nat. Immunol. 19, 475-486.
    doi: 10.1038/s41590-018-0085-3PMID:29670239
  4. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Park, RJ, Wang, T, Koundakjian, D, Hultquist, JF, Lamothe-Molina, P, Monel, B, Schumann, K, Yu, H, Krupzcak, KM, Garcia-Beltran, W et al.. 2017. Nat. Genet. 49, 193-203.
    doi: 10.1038/ng.3741PMID:27992415
  5. Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion. Ranasinghe, S, Lamothe, PA, Soghoian, DZ, Kazer, SW, Cole, MB, Shalek, AK, Yosef, N, Jones, RB, Donaghey, F, Nwonu, C et al.. 2016. Immunity 45, 917-930.
    doi: 10.1016/j.immuni.2016.09.015PMID:27760342
  6. Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. Ndhlovu, ZM, Kamya, P, Mewalal, N, Kløverpris, HN, Nkosi, T, Pretorius, K, Laher, F, Ogunshola, F, Chopera, D, Shekhar, K et al.. 2015. Immunity 43, 591-604.
    doi: 10.1016/j.immuni.2015.08.012PMID:26362266
  7. TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Chen, H, Ndhlovu, ZM, Liu, D, Porter, LC, Fang, JW, Darko, S, Brockman, MA, Miura, T, Brumme, ZL, Schneidewind, A et al.. 2012. Nat. Immunol. 13, 691-700.
    doi: 10.1038/ni.2342PMID:22683743
  8. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. International HIV Controllers Study, Pereyra, F, Jia, X, McLaren, PJ, Telenti, A, de Bakker, PI, Walker, BD, Ripke, S, Brumme, CJ, Pulit, SL et al.. 2010. Science 330, 1551-7.
    doi: 10.1126/science.1195271PMID:21051598
  9. CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Kiepiela, P, Ngumbela, K, Thobakgale, C, Ramduth, D, Honeyborne, I, Moodley, E, Reddy, S, de Pierres, C, Mncube, Z, Mkhwanazi, N et al.. 2007. Nat. Med. 13, 46-53.
    doi: 10.1038/nm1520PMID:17173051
  10. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Day, CL, Kaufmann, DE, Kiepiela, P, Brown, JA, Moodley, ES, Reddy, S, Mackey, EW, Miller, JD, Leslie, AJ, DePierres, C et al.. 2006. Nature 443, 350-4.
    doi: 10.1038/nature05115PMID:16921384

Recent Publications

  1. Toward T Cell-Mediated Control or Elimination of HIV Reservoirs: Lessons From Cancer Immunology. Mylvaganam, G, Yanez, AG, Maus, M, Walker, BD. 2019. Front Immunol 10, 2109.
    doi: 10.3389/fimmu.2019.02109PMID:31552045
  2. HIV-1 DNA sequence diversity and evolution during acute subtype C infection. Lee, GQ, Reddy, K, Einkauf, KB, Gounder, K, Chevalier, JM, Dong, KL, Walker, BD, Yu, XG, Ndung'u, T, Lichterfeld, M et al.. 2019. Nat Commun 10, 2737.
    doi: 10.1038/s41467-019-10659-2PMID:31227699
  3. Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection. Ndhlovu, ZM, Kazer, SW, Nkosi, T, Ogunshola, F, Muema, DM, Anmole, G, Swann, SA, Moodley, A, Dong, K, Reddy, T et al.. 2019. Sci Transl Med 11, .
    doi: 10.1126/scitranslmed.aau0528PMID:31118290
  4. Structural topology defines protective CD8+ T cell epitopes in the HIV proteome. Gaiha, GD, Rossin, EJ, Urbach, J, Landeros, C, Collins, DR, Nwonu, C, Muzhingi, I, Anahtar, MN, Waring, OM, Piechocka-Trocha, A et al.. 2019. Science 364, 480-484.
    doi: 10.1126/science.aav5095PMID:31048489
  5. Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members. Gonzalo-Gil, E, Rapuano, PB, Ikediobi, U, Leibowitz, R, Mehta, S, Coskun, AK, Porterfield, JZ, Lampkin, TD, Marconi, VC, Rimland, D et al.. 2019. Elife 8, .
    doi: 10.7554/eLife.44360PMID:30964004
  6. HIV Controllers Exhibit Effective CD8+ T Cell Recognition of HIV-1-Infected Non-activated CD4+ T Cells. Monel, B, McKeon, A, Lamothe-Molina, P, Jani, P, Boucau, J, Pacheco, Y, Jones, RB, Le Gall, S, Walker, BD. 2019. Cell Rep 27, 142-153.e4.
    doi: 10.1016/j.celrep.2019.03.016PMID:30943397
  7. Polarizable Force Fields for Biomolecular Simulations: Recent Advances and Applications. Jing, Z, Liu, C, Cheng, SY, Qi, R, Walker, BD, Piquemal, JP, Ren, P. 2019. Annu Rev Biophys 48, 371-394.
    doi: 10.1146/annurev-biophys-070317-033349PMID:30916997
  8. Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting. Julg, B, Dee, L, Ananworanich, J, Barouch, DH, Bar, K, Caskey, M, Colby, DJ, Dawson, L, Dong, KL, Dubé, K et al.. 2019. Lancet HIV 6, e259-e268.
    doi: 10.1016/S2352-3018(19)30052-9PMID:30885693
  9. Long-term changes in keratometry and refraction after small aperture corneal inlay implantation. Moshirfar, M, Desautels, JD, Walker, BD, Birdsong, OC, Skanchy, DF, Quist, TS, Murri, MS, Linn, SH, Hoopes, PC Jr, Hoopes, PC et al.. 2018. Clin Ophthalmol 12, 1931-1938.
    doi: 10.2147/OPTH.S164964PMID:30323549
  10. Calponins Are Recruited to Actin-Rich Structures Generated by Pathogenic Escherichia coli, Listeria, and Salmonella. Chua, MD, Walker, BD, Jin, JP, Guttman, JA. 2018. Anat Rec (Hoboken) 301, 2103-2111.
    doi: 10.1002/ar.23956PMID:30312538
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Photo credit: Howard Hughes Medical Institute