Bruce Walker

Bruce Walker

Professor of the Practice

Bruce Walker investigates cellular immune responses in chronic human viral infections, with a particular focus on HIV immunology and vaccine development.

857-268-7073

Phone

Ragon Institute, Room 870 (400 Technology Square)

Office

Marissa Ferrara

Assistant

857-268-7073

Assistant Phone

Education

  • PhD, 1993, University of Vienna
  • BS, 1989, Biology, University of Vienna

Research Summary

The overarching goal of my laboratory is to define the interplay of immunologic, virologic and host genetic factors that determine control of human viral infections, to guide vaccine development and immunotherapeutic interventions. To address this goal, we focus on HIV infection.

Awards

  • ​Bernard Fields Lectureship, 2015
  • NIH Merit Award, 2011, 2004
  • American Academy of Arts and Sciences, 2010
  • National Academy of Medicine, 2009
  • American Association of Physicians, 2000
  • Doris Duke Charitable Foundation Distinguished Clinical Scientist Award, 1999
  • American Society for Clinical Investigation, 1993

Key Publications

  1. Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection. Ndhlovu, ZM, Kazer, SW, Nkosi, T, Ogunshola, F, Muema, DM, Anmole, G, Swann, SA, Moodley, A, Dong, K, Reddy, T et al.. 2019. Sci Transl Med 11, .
    doi: 10.1126/scitranslmed.aau0528PMID:31118290
  2. Structural topology defines protective CD8+ T cell epitopes in the HIV proteome. Gaiha, GD, Rossin, EJ, Urbach, J, Landeros, C, Collins, DR, Nwonu, C, Muzhingi, I, Anahtar, MN, Waring, OM, Piechocka-Trocha, A et al.. 2019. Science 364, 480-484.
    doi: 10.1126/science.aav5095PMID:31048489
  3. Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system. Clayton, KL, Collins, DR, Lengieza, J, Ghebremichael, M, Dotiwala, F, Lieberman, J, Walker, BD. 2018. Nat Immunol 19, 475-486.
    doi: 10.1038/s41590-018-0085-3PMID:29670239
  4. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Park, RJ, Wang, T, Koundakjian, D, Hultquist, JF, Lamothe-Molina, P, Monel, B, Schumann, K, Yu, H, Krupzcak, KM, Garcia-Beltran, W et al.. 2017. Nat Genet 49, 193-203.
    doi: 10.1038/ng.3741PMID:27992415
  5. Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion. Ranasinghe, S, Lamothe, PA, Soghoian, DZ, Kazer, SW, Cole, MB, Shalek, AK, Yosef, N, Jones, RB, Donaghey, F, Nwonu, C et al.. 2016. Immunity 45, 917-930.
    doi: 10.1016/j.immuni.2016.09.015PMID:27760342
  6. Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. Ndhlovu, ZM, Kamya, P, Mewalal, N, Kløverpris, HN, Nkosi, T, Pretorius, K, Laher, F, Ogunshola, F, Chopera, D, Shekhar, K et al.. 2015. Immunity 43, 591-604.
    doi: 10.1016/j.immuni.2015.08.012PMID:26362266
  7. TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Chen, H, Ndhlovu, ZM, Liu, D, Porter, LC, Fang, JW, Darko, S, Brockman, MA, Miura, T, Brumme, ZL, Schneidewind, A et al.. 2012. Nat Immunol 13, 691-700.
    doi: 10.1038/ni.2342PMID:22683743
  8. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. International HIV Controllers Study, Pereyra, F, Jia, X, McLaren, PJ, Telenti, A, de Bakker, PI, Walker, BD, Ripke, S, Brumme, CJ, Pulit, SL et al.. 2010. Science 330, 1551-7.
    doi: 10.1126/science.1195271PMID:21051598
  9. CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Kiepiela, P, Ngumbela, K, Thobakgale, C, Ramduth, D, Honeyborne, I, Moodley, E, Reddy, S, de Pierres, C, Mncube, Z, Mkhwanazi, N et al.. 2007. Nat Med 13, 46-53.
    doi: 10.1038/nm1520PMID:17173051
  10. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Day, CL, Kaufmann, DE, Kiepiela, P, Brown, JA, Moodley, ES, Reddy, S, Mackey, EW, Miller, JD, Leslie, AJ, DePierres, C et al.. 2006. Nature 443, 350-4.
    doi: 10.1038/nature05115PMID:16921384

Recent Publications

  1. Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia. Collins, DR, Urbach, JM, Racenet, ZJ, Arshad, U, Power, KA, Newman, RM, Mylvaganam, GH, Ly, NL, Lian, X, Rull, A et al.. 2021. Immunity 54, 2372-2384.e7.
    doi: 10.1016/j.immuni.2021.08.007PMID:34496223
  2. E2EDNA: Simulation Protocol for DNA Aptamers with Ligands. Kilgour, M, Liu, T, Walker, BD, Ren, P, Simine, L. 2021. J Chem Inf Model 61, 4139-4144.
    doi: 10.1021/acs.jcim.1c00696PMID:34435773
  3. Profound Treg perturbations correlate with COVID-19 severity. Galván-Peña, S, Leon, J, Chowdhary, K, Michelson, DA, Vijaykumar, B, Yang, L, Magnuson, AM, Chen, F, Manickas-Hill, Z, Piechocka-Trocha, A et al.. 2021. Proc Natl Acad Sci U S A 118, .
    doi: 10.1073/pnas.2111315118PMID:34433692
  4. Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses. Nathan, A, Rossin, EJ, Kaseke, C, Park, RJ, Khatri, A, Koundakjian, D, Urbach, JM, Singh, NK, Bashirova, A, Tano-Menka, R et al.. 2021. Cell 184, 4401-4413.e10.
    doi: 10.1016/j.cell.2021.06.029PMID:34265281
  5. HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV. Kaseke, C, Park, RJ, Singh, NK, Koundakjian, D, Bashirova, A, Garcia Beltran, WF, Takou Mbah, OC, Ma, J, Senjobe, F, Urbach, JM et al.. 2021. Cell Rep 36, 109378.
    doi: 10.1016/j.celrep.2021.109378PMID:34260940
  6. Epigenetic Regulation of BST-2 Expression Levels and the Effect on HIV-1 Pathogenesis. Singh, R, Ramsuran, V, Naranbhai, V, Yende-Zuma, N, Garrett, N, Mlisana, K, Dong, KL, Walker, BD, Abdool Karim, SS, Carrington, M et al.. 2021. Front Immunol 12, 669241.
    doi: 10.3389/fimmu.2021.669241PMID:34025670
  7. CMV, MHC-E, and the quest for an unconventional AIDS vaccine. Walker, BD. 2021. Sci Immunol 6, .
    doi: 10.1126/sciimmunol.abi5830PMID:33990380
  8. A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies. McCann, CD, van Dorp, CH, Danesh, A, Ward, AR, Dilling, TR, Mota, TM, Zale, E, Stevenson, EM, Patel, S, Brumme, CJ et al.. 2021. J Exp Med 218, .
    doi: 10.1084/jem.20201908PMID:33988715
  9. Long noncoding RNA MIR4435-2HG enhances metabolic function of myeloid dendritic cells from HIV-1 elite controllers. Hartana, CA, Rassadkina, Y, Gao, C, Martin-Gayo, E, Walker, BD, Lichterfeld, M, Yu, XG. 2021. J Clin Invest 131, .
    doi: 10.1172/JCI146136PMID:33938445
  10. Expansion of Cytotoxic CD4+ T cells in the lungs in severe COVID-19. Kaneko, N, Boucau, J, Kuo, HH, Perugino, C, Mahajan, VS, Farmer, JR, Liu, H, Diefenbach, TJ, Piechocka-Trocha, A, Lefteri, K et al.. 2021. medRxiv , .
    doi: 10.1101/2021.03.23.21253885PMID:33791730
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Photo credit: Howard Hughes Medical Institute