Bruce Walker

Bruce Walker

Professor of the Practice; Core Member, Ragon Institute

Bruce Walker investigates cellular immune responses in chronic human viral infections, with a particular focus on HIV immunology and vaccine development.

857-268-7073

Phone

600 Main Street, Rm 384

Office

Ragon Institute of MGH, MIT and Harvard

Location

Maddie Rimsa

Assistant

857-268-7073

Assistant Phone

Education

  • PhD, 1993, University of Vienna
  • BS, 1989, Biology, University of Vienna

Research Summary

The overarching goal of my laboratory is to define the interplay of immunologic, virologic and host genetic factors that determine control of human viral infections, to guide vaccine development and immunotherapeutic interventions. To address this goal, we focus on HIV infection.

Awards

  • ​Bernard Fields Lectureship, 2015
  • NIH Merit Award, 2011, 2004
  • American Academy of Arts and Sciences, 2010
  • National Academy of Medicine, 2009
  • American Association of Physicians, 2000
  • Doris Duke Charitable Foundation Distinguished Clinical Scientist Award, 1999
  • American Society for Clinical Investigation, 1993

Key Publications

Recent Publications

  1. Evolution of Advanced Practice Provider Fellowship Training in Neurology Over 10 Years. Morgenlander, JC, Simers, LA, White, K, Walker, BD. 2024. Neurol Educ 3, e200173.
    doi: 10.1212/NE9.0000000000200173PMID:39748892
  2. Comparison of Efficacy of Micropulse Laser Settings for Glaucoma Management. Kim, EY, Walker, BD, Hopkins, NS, Fowler, S, Jerkins, BM, Kanner, EM, Wright, CL. 2024. J Clin Med 13, .
    doi: 10.3390/jcm13195753PMID:39407813
  3. Cycling of labile and recalcitrant carboxyl-rich alicyclic molecules and carbohydrates in Baffin Bay. McKee, K, Abdulla, H, O'Reilly, L, Walker, BD. 2024. Nat Commun 15, 8735.
    doi: 10.1038/s41467-024-53132-5PMID:39384842
  4. Expanded Antigen-Specific Elimination Assay to Measure Human CD8+ T Cell Cytolytic Potential. Collins, DR, Olatotse, MJ, Racenet, ZJ, Arshad, U, Çakan, E, Gaiha, GD, Clayton, KL, Walker, BD. 2024. Curr Protoc 4, e1109.
    doi: 10.1002/cpz1.1109PMID:39023416
  5. Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection. Reddy, K, Lee, GQ, Reddy, N, Chikowore, TJB, Baisley, K, Dong, KL, Walker, BD, Yu, XG, Lichterfeld, M, Ndung'u, T et al.. 2024. medRxiv , .
    doi: 10.1101/2024.02.16.24302713PMID:38947072
  6. Immunogenicity of 2 therapeutic mosaic HIV-1 vaccine strategies in individuals with HIV-1 on antiretroviral therapy. Julg, B, Stephenson, KE, Tomaka, F, Walsh, SR, Sabrina Tan, C, Lavreys, L, Sarnecki, M, Ansel, JL, Kanjilal, DG, Jaegle, K et al.. 2024. NPJ Vaccines 9, 89.
    doi: 10.1038/s41541-024-00876-2PMID:38782902
  7. Polymorphic residues in HLA-B that mediate HIV control distinctly modulate peptide interactions with both TCR and KIR molecules. Tano-Menka, R, Singh, NK, Muzhingi, I, Li, X, Mandanas, MV, Kaseke, C, Crain, CR, Zhang, A, Ogunshola, FJ, Vecchiarello, L et al.. 2024. Structure 32, 1121-1136.e5.
    doi: 10.1016/j.str.2024.04.015PMID:38733995
  8. Variable aging and storage of dissolved black carbon in the ocean. Coppola, AI, Druffel, ERM, Broek, TA, Haghipour, N, Eglinton, TI, McCarthy, M, Walker, BD. 2024. Proc Natl Acad Sci U S A 121, e2305030121.
    doi: 10.1073/pnas.2305030121PMID:38517975
  9. Impact of HLA class I functional divergence on HIV control. Viard, M, O'hUigin, C, Yuki, Y, Bashirova, AA, Collins, DR, Urbach, JM, Wolinsky, S, Buchbinder, S, Kirk, GD, Goedert, JJ et al.. 2024. Science 383, 319-325.
    doi: 10.1126/science.adk0777PMID:38236978
  10. T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19. Zonozi, R, Walters, LC, Shulkin, A, Naranbhai, V, Nithagon, P, Sauvage, G, Kaeske, C, Cosgrove, K, Nathan, A, Tano-Menka, R et al.. 2023. Sci Transl Med 15, eadh4529.
    doi: 10.1126/scitranslmed.adh4529PMID:38019932
More Publications

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Photo credit: Howard Hughes Medical Institute