Adam C. Martin

Adam C. Martin

Professor of Biology; Co-Undergraduate Officer

Adam C. Martin studies molecular mechanisms that underlie tissue form and function.

617-324-0074

Phone

68-459

Office

acmartin@mit.edu

Email

Building 68 - Koch Biology Building

Location

Lab Website
Meg Rheault

Assistant

617-253-1809

Assistant Phone

Education

  • PhD, 2006, University of California, Berkeley
  • BS, 2000, Biology and Genetics, Cornell University

Research Summary

We study how cells and tissues change shape during embryonic development, giving rise to different body parts. We visualize these changes to determine how mechanical forces drive massive tissue movements in the fruit fly, Drosophila melanogaster. In addition, we also study the regulation of tissue integrity, investigating the processes that regulate the epithelial-to-mesenchymal transition or EMT.

Recent Publications

  1. EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues in Drosophila melanogaster. Clarke, DN, Miller, PW, Martin, AC. 2025. Dev Cell 60, 270-287.e6.
    doi: 10.1016/j.devcel.2024.10.002PMID:39461341
  2. Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability in Drosophila. Jackson, JA, Denk-Lobnig, M, Kitzinger, KA, Martin, AC. 2024. Curr Biol 34, 2132-2146.e5.
    doi: 10.1016/j.cub.2024.04.021PMID:38688282
  3. Morphogenesis: Setting the pace of embryo folding. Clarke, DN, Martin, AC. 2024. Curr Biol 34, R286-R288.
    doi: 10.1016/j.cub.2024.02.053PMID:38593774
  4. Drosophila Fog/Cta and T48 pathways have overlapping and distinct contributions to mesoderm invagination. Horo, U, Clarke, DN, Martin, AC. 2024. Mol Biol Cell 35, ar69.
    doi: 10.1091/mbc.E24-02-0050PMID:38536475
  5. EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues. Clarke, DN, Martin, AC. 2023. bioRxiv , .
    doi: 10.1101/2023.12.22.573057PMID:38187543
  6. Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability in Drosophila. Jackson, JA, Denk-Lobnig, M, Kitzinger, KA, Martin, AC. 2023. bioRxiv , .
    doi: 10.1101/2023.11.06.565883PMID:37986763
  7. Live Imaging of Nurse Cell Behavior in Late Stages of Drosophila Oogenesis. Jackson, JA, Imran Alsous, J, Martin, AC. 2023. Methods Mol Biol 2626, 219-232.
    doi: 10.1007/978-1-0716-2970-3_11PMID:36715907
  8. Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation. Camuglia, J, Chanet, S, Martin, AC. 2022. Elife 11, .
    doi: 10.7554/eLife.78779PMID:35796436
  9. Current advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics. Khetan, R, Curtis, R, Deane, CM, Hadsund, JT, Kar, U, Krawczyk, K, Kuroda, D, Robinson, SA, Sormanni, P, Tsumoto, K et al.. 2022. MAbs 14, 2020082.
    doi: 10.1080/19420862.2021.2020082PMID:35104168
  10. Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature. Denk-Lobnig, M, Totz, JF, Heer, NC, Dunkel, J, Martin, AC. 2021. Development 148, .
    doi: 10.1242/dev.199232PMID:34124762
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