Adam C. Martin

Adam C. Martin

Associate Professor of Biology; Undergraduate Officer

Adam C. Martin studies molecular mechanisms that underlie tissue form and function.

617-324-0074

Phone

68-459

Office

acmartin@mit.edu

Email

Lab Website
Meg Rheault

Assistant

617-253-1809

Assistant Phone

Education

  • PhD, 2006, University of California, Berkeley
  • BS, 2000, Biology and Genetics, Cornell University

Research Summary

We study how cells and tissues change shape during embryonic development, giving rise to different body parts. We visualize these changes to determine how mechanical forces drive massive tissue movements in the fruit fly, Drosophila melanogaster. In addition, we also study the regulation of tissue integrity, investigating the processes that regulate the epithelial-to-mesenchymal transition or EMT.

Recent Publications

  1. Current advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics. Khetan, R, Curtis, R, Deane, CM, Hadsund, JT, Kar, U, Krawczyk, K, Kuroda, D, Robinson, SA, Sormanni, P, Tsumoto, K et al.. MAbs 14, 2020082.
    doi: 10.1080/19420862.2021.2020082PMID:35104168
  2. Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature. Denk-Lobnig, M, Totz, JF, Heer, NC, Dunkel, J, Martin, AC. 2021. Development 148, .
    doi: 10.1242/dev.199232PMID:34124762
  3. Actin-based force generation and cell adhesion in tissue morphogenesis. Clarke, DN, Martin, AC. 2021. Curr Biol 31, R667-R680.
    doi: 10.1016/j.cub.2021.03.031PMID:34033797
  4. Dynamics of hydraulic and contractile wave-mediated fluid transport during Drosophila oogenesis. Imran Alsous, J, Romeo, N, Jackson, JA, Mason, FM, Dunkel, J, Martin, AC. 2021. Proc Natl Acad Sci U S A 118, .
    doi: 10.1073/pnas.2019749118PMID:33658367
  5. Self-organized cytoskeletal alignment during Drosophila mesoderm invagination. Martin, AC. 2020. Philos Trans R Soc Lond B Biol Sci 375, 20190551.
    doi: 10.1098/rstb.2019.0551PMID:32829683
  6. Divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis. Denk-Lobnig, M, Martin, AC. 2020. Curr Opin Genet Dev 63, 24-29.
    doi: 10.1016/j.gde.2020.02.014PMID:32171160
  7. The Physical Mechanisms of Drosophila Gastrulation: Mesoderm and Endoderm Invagination. Martin, AC. 2020. Genetics 214, 543-560.
    doi: 10.1534/genetics.119.301292PMID:32132154
  8. Apical Constriction Reversal upon Mitotic Entry Underlies Different Morphogenetic Outcomes of Cell Division. Ko, CS, Kalakuntla, P, Martin, AC. 2020. Mol Biol Cell 31, 1663-1674.
    doi: 10.1091/mbc.E19-12-0673PMID:32129704
  9. The cellular and molecular mechanisms that establish the mechanics of Drosophila gastrulation. Ko, CS, Martin, AC. 2020. Curr Top Dev Biol 136, 141-165.
    doi: 10.1016/bs.ctdb.2019.08.003PMID:31959286
  10. Structural Redundancy in Supracellular Actomyosin Networks Enables Robust Tissue Folding. Yevick, HG, Miller, PW, Dunkel, J, Martin, AC. 2019. Dev Cell 50, 586-598.e3.
    doi: 10.1016/j.devcel.2019.06.015PMID:31353314
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