Adam C. Martin

Adam C. Martin

Associate Professor of Biology

Adam C. Martin studies molecular mechanisms that underlie tissue form and function.

617-324-0074

Phone

68-459

Office

acmartin@mit.edu

Email

Lab Website
Meg Rheault

Assistant

617-253-1809

Assistant Phone

Education

  • PhD, 2006, University of California, Berkeley
  • BS, 2000, Biology and Genetics, Cornell University

Research Summary

We study how cells and tissues change shape during embryonic development, giving rise to different body parts. We visualize these changes to determine how mechanical forces drive massive tissue movements in the fruit fly, Drosophila melanogaster. In addition, we also study the regulation of tissue integrity, investigating the processes that regulate the epithelial-to-mesenchymal transition or EMT.

Key Publications

  1. Actomyosin meshwork mechanosensing enables tissue shape to orient cell force. Chanet, S, Miller, CJ, Vaishnav, ED, Ermentrout, B, Davidson, LA, Martin, AC. 2017. Nat Commun 8, 15014.
    doi: 10.1038/ncomms15014PMID:28504247
  2. Actomyosin-based tissue folding requires a multicellular myosin gradient. Heer, NC, Miller, PW, Chanet, S, Stoop, N, Dunkel, J, Martin, AC. 2017. Development 144, 1876-1886.
    doi: 10.1242/dev.146761PMID:28432215
  3. Apical Sarcomere-like Actomyosin Contracts Nonmuscle Drosophila Epithelial Cells. Coravos, JS, Martin, AC. 2016. Dev. Cell 39, 346-358.
    doi: 10.1016/j.devcel.2016.09.023PMID:27773487
  4. Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover. Jodoin, JN, Coravos, JS, Chanet, S, Vasquez, CG, Tworoger, M, Kingston, ER, Perkins, LA, Perrimon, N, Martin, AC. 2015. Dev. Cell 35, 685-97.
    doi: 10.1016/j.devcel.2015.11.018PMID:26688336
  5. Apical domain polarization localizes actin-myosin activity to drive ratchet-like apical constriction. Mason, FM, Tworoger, M, Martin, AC. 2013. Nat. Cell Biol. 15, 926-36.
    doi: 10.1038/ncb2796PMID:23831726

Recent Publications

  1. Divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis. Denk-Lobnig, M, Martin, AC. 2020. Curr. Opin. Genet. Dev. 63, 24-29.
    doi: 10.1016/j.gde.2020.02.014PMID:32171160
  2. The Physical Mechanisms of Drosophila Gastrulation: Mesoderm and Endoderm Invagination. Martin, AC. 2020. Genetics 214, 543-560.
    doi: 10.1534/genetics.119.301292PMID:32132154
  3. Apical Constriction Reversal upon Mitotic Entry Underlies Different Morphogenetic Outcomes of Cell Division. Ko, CS, Kalakuntla, P, Martin, AC. 2020. Mol. Biol. Cell 31, 1663-1674.
    doi: 10.1091/mbc.E19-12-0673PMID:32129704
  4. The cellular and molecular mechanisms that establish the mechanics of Drosophila gastrulation. Ko, CS, Martin, AC. 2020. Curr. Top. Dev. Biol. 136, 141-165.
    doi: 10.1016/bs.ctdb.2019.08.003PMID:31959286
  5. Structural Redundancy in Supracellular Actomyosin Networks Enables Robust Tissue Folding. Yevick, HG, Miller, PW, Dunkel, J, Martin, AC. 2019. Dev. Cell 50, 586-598.e3.
    doi: 10.1016/j.devcel.2019.06.015PMID:31353314
  6. Microtubules promote intercellular contractile force transmission during tissue folding. Ko, CS, Tserunyan, V, Martin, AC. 2019. J. Cell Biol. 218, 2726-2742.
    doi: 10.1083/jcb.201902011PMID:31227595
  7. ZnUMBA Crosses the Border. Imran Alsous, J, Martin, AC. 2019. Dev. Cell 48, 423-424.
    doi: 10.1016/j.devcel.2019.02.007PMID:30782409
  8. Quantitative analysis of cell shape and the cytoskeleton in developmental biology. Yevick, HG, Martin, AC. 2018. Wiley Interdiscip Rev Dev Biol 7, e333.
    doi: 10.1002/wdev.333PMID:30168893
  9. Tension, contraction and tissue morphogenesis. Heer, NC, Martin, AC. 2017. Development 144, 4249-4260.
    doi: 10.1242/dev.151282PMID:29183938
  10. Myosin 2-Induced Mitotic Rounding Enables Columnar Epithelial Cells to Interpret Cortical Spindle Positioning Cues. Chanet, S, Sharan, R, Khan, Z, Martin, AC. 2017. Curr. Biol. 27, 3350-3358.e3.
    doi: 10.1016/j.cub.2017.09.039PMID:29107549
More Publications

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