Education
- PhD, 2002, MIT
- SB, 1996, Molecular Biology, University of Texas at Austin
Research Summary
We investigate how stem cells are regulated to regenerate missing tissues. We study the cellular events involved in this process and the attendant roles for regulatory genes that control regeneration steps. We utilize an array of methodologies, including high-throughput sequencing, RNA interference (RNAi) screening, and numerous assays and tools for phenotypic analysis to characterize regeneration regulatory genes.
Awards
- Howard Hughes Medical Institute, HHMI Investigator, 2013
Education
- PhD, 1979, Harvard University
- BA, 1972, Biophysics, Amherst College
Research Summary
Before closing his lab, Bob Sauer studied the relationship between protein structure, function, sequence and folding. He focused on the molecular machines that degrade or remodel proteins, targeting proteins for these ATP-dependent reactions. His experimental tools included biochemistry and single-molecule biophysics, structural biology, protein design and engineering, and molecular genetics.
Awards
- Protein Society, Stein and Moore Award, 2013
- Protein Society, Hans Neurath Award, 2007
- Protein Society, Amgen Award, 2001
- National Academy of Sciences, Member, 1996
- American Academy of Arts and Sciences, Fellow, 1993
Education
- MD, 1984, Harvard Medical School
- BS, 1978, Chemistry, Swarthmore College
Research Summary
We seek to understand the genetic differences between males and females — both within and beyond the reproductive tract. We study the medical ramifications of these differences in a broad context, through comparative biological, evolutionary, developmental and clinically focused analyses. Our three main veins of research relate to sex differences in health and disease, sex chromosome genomics, and germ cell origins and development.
Awards
- American Academy of Arts and Sciences, Fellow, 2012
- March of Dimes, Developmental Biology, 2011
- National Academy of Medicine, Member, 2008
- National Academy of Sciences, Member, 2005
- Howard Hughes Medical Institute, HHMI Investigator, 1990
- MacArthur Foundation, MacArthur Fellowship, 1986
Education
- PhD, 1984, Harvard University
- BA, 1977, Chemistry, University of California – San Diego
Research Summary
Before retiring from MIT, Terry Orr-Weaver investigated the processes controlling cell division and cell size during development. She studied the transition from oocyte to embryo, the regulators involved, and how this leads to cell cycle changes from meiosis to embryonic mitosis. She also aimed to delineate the coordination of cell size between tissue layers and the regulation of replication origin activation and replication fork progression.
Awards
- Federation of American Societies for Experimental Biology, Excellence in Science Award, 2013
- American Association for the Advancement of Science, Fellow, 2010
- National Academy of Sciences, Member, 2006
- American Academy of Microbiology, Fellow, 2006
Education
- PhD, 1983, MIT
- BSc, 1979, Medicinal Chemistry, University College London
Research Summary
We study diverse aspects of protein structure and function and employ multidisciplinary approaches to address fundamental problems at the interface of chemistry and biology. We are fascinated by the amazing complexity and myriad functions of glycoconjugates in human health and disease. Still more enthralling are the intricate membrane-associated pathways that lead to the cellular biogenesis of these important macromolecules. Our group applies approaches and technologies from a wide range of synergistic fields including chemical biology (for inhibitor and probe development), biochemistry and biophysics (for analyses within and beyond native and model membranes), and cellular, molecular and microbiology to unravel these pathways. Ultimately we seek to decipher the molecular logic of glycoconjugate biosynthesis and to identify processes to target in the study of infectious disease.
Awards
- National Academy of Sciences, Member, 2010
- Fellow of the Royal Society of Chemistry (FRSC) 2006
- American Chemical Society – Breslow Award for Achievement in Biomimetic Chemistry 2006
- Protein Society – Kaiser Award, 2006
- Margaret MacVicar Faculty Fellow, 2003-2013
- American Academy of Arts and Sciences, Fellow, 2001
Education
- PhD, 1979, Yale University
- BS, 1975, Biological Sciences, Indiana University
Research Summary
We use experimental and computational technologies to determine how signaling pathways, transcription factors, chromatin regulators and small RNAs regulate gene expression in healthy and diseased cells. Our interests range from the basic molecular mechanisms behind gene control to drug development for cancer and other diseases caused by gene misregulation.
Awards
- National Academy of Medicine, Member, 2019
- National Academy of Sciences, Member, 2012
Education
- PhD, 2006, University of California, Berkeley
- BS, 2000, Biology and Genetics, Cornell University
Research Summary
We study how cells and tissues change shape during embryonic development, giving rise to different body parts. We visualize these changes to determine how mechanical forces drive massive tissue movements in the fruit fly, Drosophila melanogaster. In addition, we also study the regulation of tissue integrity, investigating the processes that regulate the epithelial-to-mesenchymal transition or EMT.
Education
- PhD, 2000, Free University of Berlin
- MS, 1996, Biochemistry, Free University of Berlin
- BS, 1993, Biochemistry, Free University of Berlin
Research Summary
Our primary goal is to understand how signals and molecules are transmitted between the nucleus and cytoplasm across the nuclear envelope. We work to decipher the mechanism and structure of the machinery that executes these cellular processes.
Education
- PhD, 2011, The Johns Hopkins University School of Medicine
- BS, 2002, Molecular Biology and Biotechnology, Millersville University
Research Summary
In the Lamason lab, we investigate how intracellular bacterial pathogens hijack host cell processes to promote infection. In particular, we study how Rickettsia parkeri and Listeria monocytogenes move through our tissues via a process called cell-to-cell spread. We utilize cellular, molecular, genetic, biochemical and biophysical approaches to elucidate the mechanisms of spread in order to reveal key aspects of pathogenesis and host cell biology.
Awards
- NIH Pathway to Independence Award, 2015
Education
- PhD, 2010, MIT
- BA, 2003, Computer Science, University of California, Berkeley
- BS, 2003, Biological Engineering, University of California, Berkeley
Research Summary
The Davis lab is working to uncover how cells construct and degrade complex molecular machines rapidly and efficiently. We apply a variety of biochemical, biophysical, and structural approaches including quantitative mass spectrometry and single particle cryo-electron microscopy to understand the detailed molecular mechanisms of these processes. Ongoing projects in the lab are focused on autophagy, an essential eukaryotic protein and organelle degradation pathway, and assembly of the ribosome, which is essential in all cells.
Awards
- Sloan Research Fellowship, Alfred P. Sloan Foundation, 2021
- National Institute on Aging R00 Fellowship, 2017
- National Institute on Aging K99 Fellowship, 2015
