Education
- PhD, 2011, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich
- MSc, Biology, 2008, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich
- BSc, Biology, 2005, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich
Research Summary
We examine the interaction between cancer and immune cells. Using tumor mouse models designed to mimic tumor progression in humans, we investigate the co-evolution of the anti-tumor immune response and cancer. Understanding the interplay between tumor cells and immune cells will help develop and improve effective cancer immunotherapies.Awards
- Forbeck Fellow, 2015
Recent Publications
- Neoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous neoantigen expression. Roerden, M, Castro, AB, Cui, Y, Harake, N, Kim, B, Dye, J, Maiorino, L, White, FM, Irvine, DJ, Litchfield, K et al.. 2024. J Immunother Cancer 12, .
doi: 10.1136/jitc-2024-010249PMID:39521615 - Validation and quantification of peptide antigens presented on MHCs using SureQuant. Leddy, O, Cui, Y, Ahn, R, Stopfer, L, Choe, E, Kim, DH, Roerden, M, Spranger, S, Bryson, BD, White, FM et al.. 2024. Nat Protoc , .
doi: 10.1038/s41596-024-01076-xPMID:39438697 - Expansion of tumor-reactive CD8+ T cell clonotypes occurs in the spleen in response to immune checkpoint blockade. Morgan, DM, Horton, BL, Bhandarkar, V, Van, R, Dinter, T, Zagorulya, M, Love, JC, Spranger, S. 2024. Sci Immunol 9, eadi3487.
doi: 10.1126/sciimmunol.adi3487PMID:39270006 - Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer. Mahat, DB, Kumra, H, Castro, SA, Metcalf, E, Nguyen, K, Morisue, R, Ho, WW, Chen, I, Sullivan, B, Yim, LK et al.. 2024. bioRxiv , .
doi: 10.1101/2024.08.28.609802PMID:39257788 - Transforming ovarian cancer care by targeting minimal residual disease. Jazaeri, AA, Grisham, R, Knisely, A, Spranger, S, Zamarin, D, Hillman, RT, Lawson, BC, Burns, KH, Lee, S, Westin, SN et al.. 2023. Med 4, 755-760.
doi: 10.1016/j.medj.2023.08.004PMID:37951209 - Overcoming lung cancer immunotherapy resistance by combining nontoxic variants of IL-12 and IL-2. Horton, BL, D'Souza, AD, Zagorulya, M, McCreery, CV, Abhiraman, GC, Picton, L, Sheen, A, Agarwal, Y, Momin, N, Wittrup, KD et al.. 2023. JCI Insight 8, .
doi: 10.1172/jci.insight.172728PMID:37669107 - Decoupled neoantigen cross-presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression. Nguyen, KB, Roerden, M, Copeland, CJ, Backlund, CM, Klop-Packel, NG, Remba, T, Kim, B, Singh, NK, Birnbaum, ME, Irvine, DJ et al.. 2023. Elife 12, .
doi: 10.7554/eLife.85263PMID:37548358 - Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies. Lax, BM, Palmeri, JR, Lutz, EA, Sheen, A, Stinson, JA, Duhamel, L, Santollani, L, Kennedy, A, Rothschilds, AM, Spranger, S et al.. 2023. Proc Natl Acad Sci U S A 120, e2300895120.
doi: 10.1073/pnas.2300895120PMID:37487077 - A prime editor mouse to model a broad spectrum of somatic mutations in vivo. Ely, ZA, Mathey-Andrews, N, Naranjo, S, Gould, SI, Mercer, KL, Newby, GA, Cabana, CM, Rideout, WM 3rd, Jaramillo, GC, Khirallah, JM et al.. 2024. Nat Biotechnol 42, 424-436.
doi: 10.1038/s41587-023-01783-yPMID:37169967 - Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation. Bhagchandani, SH, Vohidov, F, Milling, LE, Tong, EY, Brown, CM, Ramseier, ML, Liu, B, Fessenden, TB, Nguyen, HV, Kiel, GR et al.. 2023. Sci Adv 9, eadg2239.
doi: 10.1126/sciadv.adg2239PMID:37075115