Monty Krieger

Monty Krieger

Whitehead Professor of Molecular Genetics

Monty Krieger studies cell surface receptors and cholesterol and their impact on normal physiology and diseases, such as heart disease and infertility.

617-253-6793

Phone

68-483

Office

krieger@mit.edu

Email

Building 68 - Koch Biology Building

Location

Cindy Woolley

Assistant

617-253-6060

Assistant Phone

Education

  • PhD, 1976, California Institute of Technology
  • BS, 1971, Chemistry, Tulane University

Research Summary

We use genetic, biochemical, physiologic, chemical, cellular and molecular biological methods to study cell surface receptor structure and function. We focus on lipoprotein receptors — in particular, the High Density Lipoprotein (HDL) receptor called Scavenger Receptor, Class B, Type I (SR-BI). Our analyses have provided insight into basic biological processes, contributed to our understanding of atherosclerosis and coronary heart disease (CHD) and have uncovered an unexpected connection between cholesterol and mammalian female infertility.

Awards 

  • Tulane University School of Science and Engineering Outstanding Alumnus Award, 2010
  • National Academy of Sciences, Member, 2009
  • Outstanding Achievement Award for Contributions to Atherosclerosis Research, International Atherosclerosis Society, 2009
  • Margaret MacVicar Faculty Fellow, 1993-2003

Key Publications

  1. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. Ungar, D, Oka, T, Brittle, EE, Vasile, E, Lupashin, VV, Chatterton, JE, Heuser, JE, Krieger, M, Waters, MG. 2002. J Cell Biol 157, 405-15.
    doi: 10.1083/jcb.200202016PMID:11980916
  2. Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice. Braun, A, Trigatti, BL, Post, MJ, Sato, K, Simons, M, Edelberg, JM, Rosenberg, RD, Schrenzel, M, Krieger, M. 2002. Circ Res 90, 270-6.
    doi: 10.1161/hh0302.104462PMID:11861414
  3. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Acton, S, Rigotti, A, Landschulz, KT, Xu, S, Hobbs, HH, Krieger, M. 1996. Science 271, 518-20.
    doi: 10.1126/science.271.5248.518PMID:8560269
  4. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Kodama, T, Freeman, M, Rohrer, L, Zabrecky, J, Matsudaira, P, Krieger, M. 1990. Nature 343, 531-5.
    doi: 10.1038/343531a0PMID:2300204
  5. Use of a mutant cell line to study the kinetics and function of O-linked glycosylation of low density lipoprotein receptors. Kozarsky, K, Kingsley, D, Krieger, M. 1988. Proc Natl Acad Sci U S A 85, 4335-9.
    doi: 10.1073/pnas.85.12.4335PMID:3380796

Recent Publications

  1. Stromal cell-derived factor-1 alpha improves cardiac function in a novel diet-induced coronary atherosclerosis model, the SR-B1ΔCT/LDLR KO mouse. Mullis, DM, Padilla-Lopez, A, Wang, H, Zhu, Y, Elde, S, Bonham, SA, Yajima, S, Kocher, ON, Krieger, M, Woo, YJ et al.. 2024. Atherosclerosis , 117518.
    doi: 10.1016/j.atherosclerosis.2024.117518PMID:38627162
  2. A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease. PrabhuDas, MR, Baldwin, CL, Bollyky, PL, Bowdish, DME, Drickamer, K, Febbraio, M, Herz, J, Kobzik, L, Krieger, M, Loike, J et al.. 2017. J Immunol 198, 3775-3789.
    doi: 10.4049/jimmunol.1700373PMID:28483986
  3. Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease. Pal, R, Ke, Q, Pihan, GA, Yesilaltay, A, Penman, ML, Wang, L, Chitraju, C, Kang, PM, Krieger, M, Kocher, O et al.. 2016. Am J Physiol Heart Circ Physiol 311, H1392-H1408.
    doi: 10.1152/ajpheart.00463.2016PMID:27694217
  4. Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport. Dockendorff, C, Faloon, PW, Yu, M, Youngsaye, W, Penman, M, Nieland, TJ, Nag, PP, Lewis, TA, Pu, J, Bennion, M et al.. 2015. ACS Med Chem Lett 6, 375-380.
    doi: 10.1021/ml500154qPMID:26478787
  5. Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Dockendorff, C, Faloon, PW, Germain, A, Yu, M, Youngsaye, W, Nag, PP, Bennion, M, Penman, M, Nieland, TJ, Dandapani, S et al.. 2015. Bioorg Med Chem Lett 25, 2594-8.
    doi: 10.1016/j.bmcl.2015.03.074PMID:25958245
  6. Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Dockendorff, C, Faloon, PW, Pu, J, Yu, M, Johnston, S, Bennion, M, Penman, M, Nieland, TJ, Dandapani, S, Perez, JR et al.. 2015. Bioorg Med Chem Lett 25, 2100-5.
    doi: 10.1016/j.bmcl.2015.03.073PMID:25900219
  7. Excess cholesterol induces mouse egg activation and may cause female infertility. Yesilaltay, A, Dokshin, GA, Busso, D, Wang, L, Galiani, D, Chavarria, T, Vasile, E, Quilaqueo, L, Orellana, JA, Walzer, D et al.. 2014. Proc Natl Acad Sci U S A 111, E4972-80.
    doi: 10.1073/pnas.1418954111PMID:25368174
  8. Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease. Tsukamoto, K, Mani, DR, Shi, J, Zhang, S, Haagensen, DE, Otsuka, F, Guan, J, Smith, JD, Weng, W, Liao, R et al.. 2013. Proc Natl Acad Sci U S A 110, 17023-8.
    doi: 10.1073/pnas.1315986110PMID:24082102
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