Education
- PhD, 1993, Harvard University
- BA, 1982, Biology, Goshen College
Research Summary
We study microRNAs and other small RNAs that specify the destruction and/or translational repression of mRNAs. We also study mRNAs, focusing on their untranslated regions and poly(A) tails, and how these regions recruit and mediate regulatory phenomena.Awards
- National Academy of Sciences, Member, 2011
- Howard Hughes Medical Institute, HHMI Investigator, 2005
- National Academy of Sciences Award in Molecular Biology, 2005
- AAAS Newcomb Cleveland Prize, 2002
Key Publications
- The molecular basis of coupling between poly(A)-tail length and translational efficiency. Xiang, K, Bartel, DP. 2021. Elife 10, .
doi: 10.7554/eLife.66493PMID:34213414 - The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation. Shi, CY, Kingston, ER, Kleaveland, B, Lin, DH, Stubna, MW, Bartel, DP. 2020. Science 370, .
doi: 10.1126/science.abc9359PMID:33184237 - The biochemical basis of microRNA targeting efficacy. McGeary, SE, Lin, KS, Shi, CY, Pham, TM, Bisaria, N, Kelley, GM, Bartel, DP. 2019. Science 366, .
doi: 10.1126/science.aav1741PMID:31806698 - Excised linear introns regulate growth in yeast. Morgan, JT, Fink, GR, Bartel, DP. 2019. Nature 565, 606-611.
doi: 10.1038/s41586-018-0828-1PMID:30651636 - A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain. Kleaveland, B, Shi, CY, Stefano, J, Bartel, DP. 2018. Cell 174, 350-362.e17.
doi: 10.1016/j.cell.2018.05.022PMID:29887379
Recent Publications
- Functional microRNA targeting without seed pairing. Hall, MH, Wang, PY, Pham, TM, Bartel, DP. 2025. Nucleic Acids Res 53, .
doi: 10.1093/nar/gkaf1018PMID:41099710 - Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation. Ray, GJ, Nardini, E, Keys, HR, Lin, DH, Sabatini, DM, Bartel, DP. 2025. bioRxiv , .
doi: 10.1101/2025.09.09.674968PMID:40964324 - 5' untranslated regions tune Toxoplasma translation. Peters, ML, Shukla, A, Gotthold, ZA, McCormick, DM, Xiang, K, Bartel, DP, Lourido, S. 2025. bioRxiv , .
doi: 10.1101/2025.07.14.664749PMID:40791393 - Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells. Khalizeva, E, Latifkar, A, Bartel, DP, Ly, J, Cheeseman, IM. 2025. bioRxiv , .
doi: 10.1101/2025.07.22.666109PMID:40777404 - PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility. Xiang, K, Bartel, DP. 2025. Nat Commun 16, 7079.
doi: 10.1038/s41467-025-62171-5PMID:40750633 - Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders. Yang, J, Xu, Y, Ziehr, DR, Taylor, MS, Valenstein, ML, Frenkel, EM, Bush, JR, Rutter, K, Stevanovski, I, Shi, CY et al.. 2025. Science 389, eado2403.
doi: 10.1126/science.ado2403PMID:40674500 - The structural basis for RNA slicing by human Argonaute2. Mohamed, AA, Wang, PY, Bartel, DP, Vos, SM. 2025. Cell Rep 44, 115166.
doi: 10.1016/j.celrep.2024.115166PMID:39932188 - Nuclear release of eIF1 restricts start-codon selection during mitosis. Ly, J, Xiang, K, Su, KC, Sissoko, GB, Bartel, DP, Cheeseman, IM. 2024. Nature 635, 490-498.
doi: 10.1038/s41586-024-08088-3PMID:39443796 - Widespread destabilization of Caenorhabditis elegans microRNAs by the E3 ubiquitin ligase EBAX-1. Stubna, MW, Shukla, A, Bartel, DP. 2024. RNA 31, 51-66.
doi: 10.1261/rna.080276.124PMID:39433399 - The structural basis for RNA slicing by human Argonaute2. Mohamed, AA, Wang, PY, Bartel, DP, Vos, SM. 2024. bioRxiv , .
doi: 10.1101/2024.08.19.608718PMID:39229170
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