Education
- PhD, 1987, Case Western Reserve University; MD, 1989, Case Western Reserve University
- BS, 1981, Chemistry with Concentration in Solid-State and Polymer Physics, Cornell University
Research Summary
Our goal is to understand how signaling pathways are integrated at the molecular and systems levels to control cellular responses. We have two main focuses: First, we study signaling pathways and networks that control cell cycle progression and DNA damage responses in cancer and cancer therapy. Second, we examine the cross-talk between inflammation, cytokine signaling and cancer. Much of our work focuses on how modular protein domains and kinases work together to build molecular signaling circuits, and how this information can be used to design synergistic drug combinations for the personalized treatment of human disease.
Awards
- MacVicar Faculty Fellow, 2021
- Fellow, Association of American Physicians, 2021
- Teaching with Digital Technology Award, 2018
Education
- PhD, 2008, University of Michigan; MD, 2008, University of Michigan Medical School
- BS, 1999, Biochemistry and Physics, University of Michigan
Research Summary
The adult intestine is maintained by stem cells that require a cellular neighborhood, or niche, consisting in part of Paneth cells. Our laboratory will investigate the molecular mechanisms of how intestinal stem cells and their Paneth cell niche respond to diverse diets to coordinate intestinal regeneration with organismal physiology and its impact on the formation and growth of intestinal cancers. By better understanding how intestinal stem cells adapt to diverse diets, we hope to identify and develop new strategies that prevent and reduce the growth of cancers involving the intestinal tract that includes the small intestine, colon, and rectum.
Awards
- AAAS Martin and Rose Wachtel Cancer Research Award, 2018
- Pew-Stewart Trust Scholar, 2016-2020
- Sidney Kimmel Scholar, 2016-2020
- V Foundation Scholar, 2014-2017
- Harold M. Weintraub Award, 2007
Education
- PhD, 1971, Brandeis University
- BS, 1966, Biology, Brandeis University
Research Summary
We use genetic approaches to identify the molecular basis of human disease pathology. More specifically, we develop strategies to combat three major disease areas: cancer, trinucleotide repeat disorders like Huntington’s disease, and cardiovascular disease.
Awards
- National Academy of Medicine, Member, 1997
- National Academy of Sciences, Member, 1994
Education
- PhD, 1988, University of California, San Francisco
- SB, 1983, Biology, Harvard University
Research Summary
Dr. Jacks’ research has focused on developing new methods for the construction and characterization of genetically engineered mouse models or GEMMs of human cancer, and recently has moved into the burgeoning area of tumor immunology to understand the interactions between the immune system and cancer. His group has produced GEMMs with constitutive and conditional mutations in several tumor suppressor genes, oncogenes, and genes involved in oxidative stress, DNA repair and epigenetic control of gene expression. These GEMMS have been used to examine the mechanism of tumor initiation and progression, to uncover the molecular, genetic and biochemical relationship to the human diseases, as tools to study response and resistance to chemotherapy, and to explore methods in molecular imaging and early detection of cancer.
Awards
- AACR Princess Takamatsu Memorial Lectureship, 2020
- Massachusetts Institute of Technology, James R Killian Jr Faculty Achievement Award, 2015
- Sergio Lombroso Award in Cancer Research, 2015
- American Academy of Arts and Sciences, Fellow, 2012
- National Academy of Sciences, Member, 2009
- Institute of Medicine of the National Academies, Member, 2009
- Paul Marks Prize for Cancer Research, 2005
- Howard Hughes Medical Institute, HHMI Investigator, 1994
Education
- PhD, 1969, University of Illinois, Urbana-Champaign
- BA, 1966, Chemistry and Math, Union College
Research Summary
We investigate small, non-coding RNAs called microRNAs (miRNAs), which regulate over half of the genes in mammalian cells at the stages of translation and mRNA stability. We are also interested in the processes underlying transcription from the anti-sense strand (so-called “divergent” transcription), as well as the relationship between elongation of transcription, RNA splicing, and chromatin modifications.
Awards
- AACR Award for Lifetime Achievement in Cancer Research, 2020
- AACR Distinguished Award for Extraordinary Scientific Innovation and Exceptional Leadership in Cancer Research and Biomedical Science, 2018
- Royal Society of London, Foreign Fellow, 2011
- National Science Foundation, National Medal of Science, 2004
- The Nobel Foundation, Nobel Prize in Physiology or Medicine, 1993
- National Academy of Medicine, Member, 1991
- American Association for the Advancement of Science, Fellow, 1987
- American Academy of Arts and Sciences, Fellow, 1987
- National Academy of Sciences, Member, 1983
Education
- PhD, 2011, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich
- MSc, Biology, 2008, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich
- BSc, Biology, 2005, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich
Research Summary
We examine the interaction between cancer and immune cells. Using tumor mouse models designed to mimic tumor progression in humans, we investigate the co-evolution of the anti-tumor immune response and cancer. Understanding the interplay between tumor cells and immune cells will help develop and improve effective cancer immunotherapies.
Awards
Education
- PhD, 1990, Stanford University
- BS, 1982, Biology, Wuhan University
Research Summary
We seek to understand the immune system and its application in cancer immunotherapy and vaccine development. We study the molecular and cellular mechanisms behind immunological and disease processes, leveraging the vast array of genomic data, humanized mice and clinical samples.
Awards
- American Association for the Advancement of Science, Fellow, 2012
