Angelika Amon

Angelika Amon

Kathleen and Curtis Marble Professor of Cancer Research; Investigator, Howard Hughes Medical Institute

Angelika Amon examines cell growth and division, and how errors in this process contribute to cancer and aging.

617-258-8964

Phone

76-561

Office

Jenny Cimino

Assistant

617-258-6559

Assistant Phone

Education

PhD, 1993, University of Vienna

Research Summary

We study cell growth and division. Specifically, we investigate how macromolecule biosynthesis is coordinated with cell division, and how chromosome segregation is is regulated by intracellular and extracellular cues. We also analyze the consequences of chromosome mis-segregation on cell and organismal physiology, and how these repercussions can lead to cancer and aging.

Awards

  • American Academy of Arts and Sciences, Member 2017
  • Elected Foreign Associate to EMBO, 2015
  • Elected Foreign Associate to the Austrian Academy of Sciences, 2015
  • Genetics Society of America Medal, 2014
  • Ernst Jung Prize for Medicine, 2013
  • National Academy of Sciences, Member, 2010
  • National Academy of Sciences Award in Molecular Biology, 2008
  • Paul Marks Prize, 2007
  • ASBMB Amgen Award, 2007
  • Alan T. Waterman Award, 2003
  • Eli Lilly and Company Research Award, 2003
  • Howard Hughes Medical Institute, HHMI Investigator, 2000

Key Publications

  1. Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System. Santaguida, S, Richardson, A, Iyer, DR, M'Saad, O, Zasadil, L, Knouse, KA, Wong, YL, Rhind, N, Desai, A, Amon, A. 2017. Dev. Cell 41, 638-651.e5.
    doi: 10.1016/j.devcel.2017.05.022PMID: 28633018
  2. Aneuploidy Causes Non-genetic Individuality. Beach, RR, Ricci-Tam, C, Brennan, CM, Moomau, CA, Hsu, PH, Hua, B, Silberman, RE, Springer, M, Amon, A. 2017. Cell 169, 229-242.e21.
    doi: 10.1016/j.cell.2017.03.021PMID: 28388408
  3. Single-chromosome Gains Commonly Function as Tumor Suppressors. Sheltzer, JM, Ko, JH, Replogle, JM, Habibe Burgos, NC, Chung, ES, Meehl, CM, Sayles, NM, Passerini, V, Storchova, Z, Amon, A. 2017. Cancer Cell 31, 240-255.
    doi: 10.1016/j.ccell.2016.12.004PMID: 28089890
  4. Spatial signals link exit from mitosis to spindle position. Falk, JE, Tsuchiya, D, Verdaasdonk, J, Lacefield, S, Bloom, K, Amon, A. 2016. Elife 5, .
    doi: 10.7554/eLife.14036PMID: 27166637
  5. Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis. Berchowitz, LE, Kabachinski, G, Walker, MR, Carlile, TM, Gilbert, WV, Schwartz, TU, Amon, A. 2015. Cell 163, 406-18.
    doi: 10.1016/j.cell.2015.08.060PMID: 26411291

Recent Publications

  1. Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis. Tang, YC, Yuwen, H, Wang, K, Bruno, PM, Bullock, K, Deik, A, Santaguida, S, Trakala, M, Pfau, SJ, Zhong, N et al.. 2017. Cancer Res. 77, 5272-5286.
    doi: 10.1158/0008-5472.CAN-17-0049PMID: 28775166
  2. Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System. Santaguida, S, Richardson, A, Iyer, DR, M'Saad, O, Zasadil, L, Knouse, KA, Wong, YL, Rhind, N, Desai, A, Amon, A. 2017. Dev. Cell 41, 638-651.e5.
    doi: 10.1016/j.devcel.2017.05.022PMID: 28633018
  3. Aneuploidy Causes Non-genetic Individuality. Beach, RR, Ricci-Tam, C, Brennan, CM, Moomau, CA, Hsu, PH, Hua, B, Silberman, RE, Springer, M, Amon, A. 2017. Cell 169, 229-242.e21.
    doi: 10.1016/j.cell.2017.03.021PMID: 28388408
  4. Single-chromosome Gains Commonly Function as Tumor Suppressors. Sheltzer, JM, Ko, JH, Replogle, JM, Habibe Burgos, NC, Chung, ES, Meehl, CM, Sayles, NM, Passerini, V, Storchova, Z, Amon, A. 2017. Cancer Cell 31, 240-255.
    doi: 10.1016/j.ccell.2016.12.004PMID: 28089890
  5. The pleiotropic deubiquitinase Ubp3 confers aneuploidy tolerance. Dodgson, SE, Santaguida, S, Kim, S, Sheltzer, J, Amon, A. 2016. Genes Dev. 30, 2259-2271.
    doi: 10.1101/gad.287474.116PMID: 27807036
  6. LTE1 promotes exit from mitosis by multiple mechanisms. Falk, JE, Campbell, IW, Joyce, K, Whalen, J, Seshan, A, Amon, A. 2016. Mol. Biol. Cell 27, 3991-4001.
    doi: 10.1091/mbc.E16-08-0563PMID: 27798238
  7. Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo. Pfau, SJ, Silberman, RE, Knouse, KA, Amon, A. 2016. Genes Dev. 30, 1395-408.
    doi: 10.1101/gad.278820.116PMID: 27313317
  8. Spatial signals link exit from mitosis to spindle position. Falk, JE, Tsuchiya, D, Verdaasdonk, J, Lacefield, S, Bloom, K, Amon, A. 2016. Elife 5, .
    doi: 10.7554/eLife.14036PMID: 27166637
  9. No current evidence for widespread dosage compensation in S. cerevisiae. Torres, EM, Springer, M, Amon, A. 2016. Elife 5, e10996.
    doi: 10.7554/eLife.10996PMID: 26949255
  10. A System to Study Aneuploidy In Vivo. Pfau, SJ, Amon, A. 2015. Cold Spring Harb. Symp. Quant. Biol. 80, 93-101.
    doi: 10.1101/sqb.2015.80.027193PMID: 26936868
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Photo credit: Theresa Weis