Can be repeated for credit. Fee: $85.00
Instructors: Dr. Mandana Sassanfar, Lori Ling
Course can be taken for credit or non-credit. Auditors are welcome.
Instructor: Prof. Jason K. Sello, Ph.D.
Jan 6*, 7, 8, 14, 15, 16, 21, 22, 27, 28, 29, 30*, 3:30pm - 5:00pm, 68-180 (class will be held in 68-121 on Jan 6 and 30)
Register for 7.931 Special Subject in Biology for Graduate Students
Pre-register for IAP subjects by Friday, January 3, 2014 by 5pm.
After January 3rd, course can be added by submitting an add/drop/change form.
An antibiotic is defined as a small molecule produced by a microorganism that kills or compromises the growth of another microorganism. These molecules are likely to be used for chemical defense in Nature, but they have long been exploited in biological research, biotechnology, and medicine. In this course, we will address the following questions:
Which microorganisms produce antibiotics?
How are antibiotics discovered and structurally characterized?
How do the major structural classes of antibiotics work?
What are the bases of antibiotic resistance?
How are the major structural classes of antibiotics biosynthesized?
How is antibiotic biosynthesis integrated into microbial physiology?
How are the major structural classes of antibiotics made by man?
How are antibiotics used in Nature, the laboratory, and the clinic?
This course is designed to highlight the connections between chemistry and biology. A wide array of topics at the interface of chemistry and biology will be covered. It is open to students with backgrounds in the biological and/or the physical sciences. It is expected that students with strong backgrounds in chemistry will learn fundamental concepts in biology; those with a strong knowledge in biology will learn fundamental concepts in chemistry. Some familiarity with basic concepts of organic chemistry, biochemistry, and genetics will be assumed.
This course includes lectures, in-class discussions, and problem sets.
Instructor: Prof. Jason K. Sello is currently the M. L. K., Jr. Visiting Associate Professor of Biology at MIT and an Associate Professor in the Department of Chemistry at Brown University. Prior to his appointment at Brown, Prof. Sello was a visiting scientist at the John Innes Centre in Norwich, England and a post-doctoral research fellow at Harvard Medical School with Prof. Christopher T. Walsh. He earned a Ph.D. in biophysics from Harvard University in 2002 under the supervision of Prof. Stuart L. Schreiber and a B.S. in biology from Morehouse College in 1997. In his independent career, Prof. Sello has been synergistically using experimental methods from chemistry, molecular biology, biochemistry, and genomics to develop new anti-infectives and biotechnology platforms for the conversion of plant biomass to biofuels and commodity chemicals. At MIT, he is working collaboratively with Prof. Robert T. Sauer in the Department of Biology on antibacterial agents that act by critically perturbing protein turnover in bacteria.
Contact info: Prof. Jason Sello - email@example.com
Life After MIT: A Sampling of Careers in Science
This program will cover non-traditional paths for Biology PhDs. Please join us at six exciting seminars featuring speakers who are at the top of these respective fields.
Government and Policy Panel
Amanda Arnold, MSc, Senior Policy Advisor, MIT Washington Office
Zofia Gajdos, PhD, Lecturer and Curriculum Fellow in Microbiology and Immunology, Harvard University
Ellie Graeden, PhD, Director of Strategic Systems Analysis, Gryphon Scientific
David Healey, PhD Candidate, Gore Lab, MIT Department of Biology
A scientist’s skills need not be applied only to the lab and classroom. Come find out how scientists can employ their expertise in government and policy agencies, playing a role in shaping research infrastructure and public perception and understanding of science!
Wednesday, January 8th, 1–3pm, 68-181
A Career in Venture Capital/Consulting
Kevin Starr, Partner at Third Rock Ventures
Carlos Loya, Scientist II in Drug Discovery at Sage Therapeutics’
David Weingeist, Senior Consultant at Simon-Kucher & Partners
Shalia Rahman, VenureLabs Associate at Flagship Ventures
The business of Biology is booming! This seminar features capitalists, who finance biological enterprises, and consultants, who suggest the best way to merge Biology with business. Come listen and speak with PhDs who have made the transition from bench work to the business world.
Thursday, January 9th, 1–3pm, McGovern Auditorium, Whitehead Institute
Science Writing Panel
Ann Cheung, PhD, Scientific Editor, Cancer Cell
Elizabeth McKenna, PhD, Science Writer, Cancer Discovery
Joanne Kotz, PhD, Director of Scientific Outreach, Broad Institute Center for the Science of Therapeutics
Thomas Levenson, Professor of Science Writing, MIT
Richard Saltus, Senior Science Writer at Dana-Farber
How can we apply our scientific training to effective communication, both among scientists and to the public? Come learn about the different ways our panelists have ventured into science writing as editors, writers, and communicators with broad audiences.
Monday, January 13th, 1–3pm, 68-181
A Career in the Biotechnology Industry
Michael Schlabach, Lab Head at Novartis
Rami Rahal, Lab Head at Blueprint Medicines
Ashok Chander, CEO at Cellanyx Diagnostics
Charles Kung, Associate Director of Biology at Agios Pharmaceuticals
Are you considering a job in industry or perhaps starting your own company? What are the main differences between academic and industry labs? Join us for an exciting Q&A session with a panel of scientists who belong to different areas of industry, and find out whether industry is right for you.
Thursday, January 16th, 1–3pm, 68-181
David Bartel, Whitehead Institute, Professor
John Prince, Novartis, Functional Patent Head
Lauren Foster, Koch Institue
Min Wang, Agios, Senior Director of IP and Legal Affairs
Speakers will share their path to the field of Patent Law, and interact with those who are interested in a career in Patent Law.
Tuesday, January 21st, 1–3pm, 68-181
Education & Outreach
Berri Jacque, PhD, Research Assistant Professor, Co-Director of the Center for Translational Science Education, Tufts Medical School
Irene Porro, PhD, Leadership Team for Fenix Center for Innovative Schools
Leslie McClain, PhD, Education and Diversity Program Manager for NSF Science and Technology Center EBICS (Emergent Behaviors of Integrated Cellular Systems)
Tyler Dewitt, PhD, Education Consultant and Teaching Lead, Socratic.org
Do you enjoy teaching and helping people learn? Come hear about careers that are focused on science education and science outreach and learn how you can share your love of science with the public.
Tuesday, January 28th, 1–3pm, 68-181
Life After MIT: Taking the Next Step in Academic Science
MIT Biology presents a selection of talks on the practice of science, navigating academia, and balancing it all with a life outside the lab
Andrew Murray, Professor, Harvard
Hidde Ploegh, Professor, MIT
Barbara Spalholz, Chief, Cancer Cell Biology Branch, NCI
Charles Morrow, Scientific Review Officer, NIH
Getting grants is critical to both starting and maintaining your research lab. Come hear from faculty who have been through the process from both the application and review side, and from NIH program officers familiar with the grant application process.
Tuesday, January 7th, 1–3pm, 68-181
Finding a Faculty Position
Stephen Bell, Professor of Biology, MIT and HHMI Investigator
Jing-Ke Weng, Assistant Professor of Biology, MIT
Omer Yilmaz, Assistant Professor of Biology, MIT
Wendy Garrett, Assistant Professor at the Harvard School of Public Health, Harvard Medical School and Dana-Farber Cancer Institute
The search for a faculty position is a daunting process. What type of institution should you apply to? What do search committees look for? And how should you prepare for the interview? Come hear the perspectives of different institutions and faculty at different stages in their careers.
Friday, January 10th, 10am–12pm, 68-181
New Professor Experience
Stephen Fuchs, Assistant Professor, Tufts University
Mary Gehring, Assistant Professor, MIT/Whitehead Institute
Michael Goldberg, Assistant Professor, Harvard Medical School
Jennifer Trowbridge, Assistant Professor, The Jackson Laboratory/Tufts University School of Medicine
What are some of the biggest challenges when setting up a lab? What turned out to be easier than expected? What is it like teaching? What about hiring lab members? Come learn from faculty at different kinds of institutions what it’s like to be a new professor!
Tuesday, January 14th, 1–3pm, 68-181
Finding the Right Post Doc
Alan Grossman, Praecis Professor of Biology; Associate Department Head; Director of Scientific Operations
Alexandra Grassian, Presidential Postdoctoral Fellow, Novartis Institutes for BioMedical Research
Justin Pritchard, Lab Head Experimental/Computational Biology, Ariad Pharmaceuticals
Raquel Deering, Postdoctoral Fellow, Novartis Institutes for BioMedical Research
Not sure if you want to do an industry or an academic postdoc? Want to know how to find a postdoc? What do people look for when hiring a postdoc? Come find out!
Wednesday, January 22nd, 1–3pm, 68-181
Thriving at MIT
Frank Solomon, Professor of Biology, MIT
Susanna (Zan) Barry, Senior Program Manager, Community Wellness at MIT Medical
Batula Zaidi, Co-chair of the Whitehead Postdoctoral Association
Biology graduate students from the BioRefs
When you’re stressed about lab or life in general, do you ever wonder what’s available to you to help you de-stress? Stressed or not, want some more information about how to improve different aspects of your mental and physical well-being? These knowledgeable panelists will share tips and ways to make your time at MIT more enjoyable.
Wednesday, January 29th, 1–3pm, 68-181
Lauren O’Connell, Bauer Fellow, Center for Systems Biology, Harvard University
Sebastian Lourido, Whitehead Fellow, Whitehead Institute, MIT
Angelika Amon, former Whitehead Fellow, Koch Cancer Center, MIT
Are you ready to be your own boss and start your own lab? Is another 4 years of work as a postdoc just not appealing to you? Come learn about becoming a Fellow instead! Hear from current and past Fellows and find out if becoming a Fellow is right for you!
Thursday, January 30th, 1–3pm, McGovern Auditorium, Whitehead Institute
The Impact of Chemistry on Understanding Biology
Chipperfield Lecture Assistant Professor, Department of Medicine, Harvard Medical School“
Chemical Modulation of Chromatin Structure and Function”
Tuesday, January 7th 4pm–5pm, 32-123
Associate Professor, Department of Chemistry, Brown University and MLK Jr. Visiting Associate Professor of Biology at MIT
“Chemical Genetics and the Genetics of Chemistry”
Wednesday, January 8th11am–noon, 76-156
Novartis Professor of Chemistry; Professor of Biology, MIT
“Homeostasis: Controlling Metallation and Oxygen Sensitivity: Ribnucleotide Reductases as a Paradigm”
Tuesday, January 14th11am–noon, 76-156
Professor of Cell Biology, Harvard Medical School
“New Insights Into Proteasome Function: From Protein Degradation to Cancer and Neurodegeneration”
Wednesday, January 22nd10am–11am, 76-156
Assistant Professor, Department of Biological Engineering, MIT
“Modulating Transcriptional Regulation using Small Molecules”
Friday, January 31st11am–noon, 76-156
Global Head of Oncology, Novartis Institutes for BioMedical Research (NIBR)
“The Genetic Basis for Cancer Therapeutics”
Monday, February 3rd 4pm–5pm, 76-156
Presented by the Biology Department and Biology Graduate Students at MIT. Web: https://biology.mit.edu/about/iapContact: Matt Vander Heiden, 76-561, firstname.lastname@example.org
There is an increasing demand for computational and quantitative methodology in the biological sciences as the techniques in the field begin to produce ever vaster amounts of data. In this short course you will be introduced to programming in Python, the de facto standard language used in scientific computing, and how to leverage its ease of use and powerful external libraries for use with biology. You will learn the basics of the language, the solutions to common computational problems encountered in research, and how to use these skills to analyze and produce interesting questions from common biological data.
Discussion panel, with faculty and Elsevier editors from Journal of Molecular Biology and Molecular Cell