Education
- Graduate: PhD, 1995, International School of Advanced Studies
- Undergraduate: BSc, 1991, University of Buenos Aires
Research Summary
B lymphocytes are the fulcrum of our immunological memory, the source of antibodies, and the focus of vaccine development. My lab has investigated how, where, and when B cell responses take shape. In recent years, my group has expanded into preclinical vaccinology, developing cutting-edge humanized mouse models for diseases including malaria, HIV, and SARS-CoV-2.Awards
- Fellow, Ministero degli Affari Esteri of Italy, 1991-1992
- Fellow, UNIDO-International Centre for Genetic Engineering and Biotechnology, 1993-1995
- Fellow, Cancer Research Institute, 1995
- Long Term Postdoctoral Fellowship, European Molecular Biology Organization, 1996-1997
- Project Grant, Arthritis Research Campaign, 1999
- Young Investigator Award, European Molecular Biology Organization, 2004
- The Royal Society Wolfson Research Merit Award, The Royal Society/The Wolfson Foundation, 2009
- Faculty of 1000, 2009
- EMBO Member, European Molecular Biology Organization, 2009
- Fellow, British Academy of Medical Sciences, 2013
- Fellow, American Academy of Microbiology, 2017
- Member, Academia de Ciencias de América Latina (ACAL), 2022
Key Publications
- Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses. Tas, JMJ, Koo, JH, Lin, YC, Xie, Z, Steichen, JM, Jackson, AM, Hauser, BM, Wang, X, Cottrell, CA, Torres, JL et al.. 2022. Immunity 55, 1856-1871.e6.
doi: 10.1016/j.immuni.2022.07.020PMID:35987201 - Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies. Kratochvil, S, Shen, CH, Lin, YC, Xu, K, Nair, U, Da Silva Pereira, L, Tripathi, P, Arnold, J, Chuang, GY, Melzi, E et al.. 2021. Immunity 54, 2859-2876.e7.
doi: 10.1016/j.immuni.2021.10.017PMID:34788599 - Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors. Wang, X, Ray, R, Kratochvil, S, Melzi, E, Lin, YC, Giguere, S, Xu, L, Warner, J, Cheon, D, Liguori, A et al.. 2021. EMBO J 40, e105926.
doi: 10.15252/embj.2020105926PMID:33258500 - Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells. Gaya, M, Barral, P, Burbage, M, Aggarwal, S, Montaner, B, Warren Navia, A, Aid, M, Tsui, C, Maldonado, P, Nair, U et al.. 2018. Cell 172, 517-533.e20.
doi: 10.1016/j.cell.2017.11.036PMID:29249358 - A switch from canonical to noncanonical autophagy shapes B cell responses. Martinez-Martin, N, Maldonado, P, Gasparrini, F, Frederico, B, Aggarwal, S, Gaya, M, Tsui, C, Burbage, M, Keppler, SJ, Montaner, B et al.. 2017. Science 355, 641-647.
doi: 10.1126/science.aal3908PMID:28183981