Education
- PhD, 2015, Johns Hopkins University School of Medicine
- BA, 2009, Molecular Biology & Biochemistry/Physics, Wesleyan University
Research Summary
We investigate crosstalk between CD8+ T cells and their environment at a molecular level, by dissecting the biological and metabolic programs engaged under conditions of stress. Using an array of approaches to model and perturb the local microenvironment, our research aims to reveal both the adaptive molecular changes as well as intrinsic vulnerabilities in T cells that arise within the tumor niche. Our goal is to understand how disease states remodel the fundamental mechanisms that regulate immune cell function and contribute to pathogenesis.Awards
- Forbeck Scholar, 2021
Key Publications
- Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Ringel, AE, Drijvers, JM, Baker, GJ, Catozzi, A, García-Cañaveras, JC, Gassaway, BM, Miller, BC, Juneja, VR, Nguyen, TH, Joshi, S et al.. 2020. Cell 183, 1848-1866.e26.
doi: 10.1016/j.cell.2020.11.009PMID:33301708 - Chemical and Physiological Features of Mitochondrial Acylation. Ringel, AE, Tucker, SA, Haigis, MC. 2018. Mol Cell 72, 610-624.
doi: 10.1016/j.molcel.2018.10.023PMID:30444998 - Nucleosome competition reveals processive acetylation by the SAGA HAT module. Ringel, AE, Cieniewicz, AM, Taverna, SD, Wolberger, C. 2015. Proc Natl Acad Sci U S A 112, E5461-70.
doi: 10.1073/pnas.1508449112PMID:26401015 - Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2. Ringel, AE, Roman, C, Wolberger, C. 2014. Protein Sci 23, 1686-97.
doi: 10.1002/pro.2546PMID:25200501