Education
- PhD, 2011, University of São Paulo Heart Institute
- MSc, Molecular Biology, 2008, University of Brasilia
- BS, 2005, Biology, University of Brasilia
Research Summary
By utilizing an innovative and intersectional approach, our lab main goal is to reveal fundamental immune-related pathways that modulate organ and tissue physiology. Our work will help to develop new strategies to tune these molecular pathways in health and disease, leading to the development of much-needed therapeutic approaches for human diseases.Awards
- CAPES Thesis Award - Brazil, 2012
Key Publications
- Leukocyte Heterogeneity in Adipose Tissue, Including in Obesity. Weinstock, A, Moura Silva, H, Moore, KJ, Schmidt, AM, Fisher, EA. 2020. Circ Res 126, 1590-1612.
doi: 10.1161/CIRCRESAHA.120.316203PMID:32437300 - Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges. Silva, HM, Báfica, A, Rodrigues-Luiz, GF, Chi, J, Santos, PDA, Reis, BS, Hoytema van Konijnenburg, DP, Crane, A, Arifa, RDN, Martin, P et al.. 2019. J Exp Med 216, 786-806.
doi: 10.1084/jem.20181049PMID:30862706 - CX3CR1+ monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF-α. Garré, JM, Silva, HM, Lafaille, JJ, Yang, G. 2017. Nat Med 23, 714-722.
doi: 10.1038/nm.4340PMID:28504723 - c-MAF dependent perivascular macrophages regulate diet induced metabolic syndrome. Silva, H.M., Kitoko, J.Z., Queiroz, C.P., Kroehling, L., Matheis, F., Yang, K.L., Ren-Fielding, C., Littman, D.R., Bozza, M.T., Mucida, D., and Lafaille, J.J. 2021. bioRxiv.
doi: https://doi.org/10.1101/2021.02.07.430147