Yadira Soto-Feliciano

Yadira Soto-Feliciano

Assistant Professor of Biology; Intramural Faculty, Koch Institute

Yadira Soto-Feliciano studies chromatin and epigenetic regulation in normal development and cancer.

617-253-3026

Phone

76-561C

Office

Koch Institute for Integrative Cancer Research

Location

Paul Thompson

Assistant

617-258-0480

Assistant Phone

Education

  • PhD, 2016, MIT
  • BS, 2008, Chemistry, University of Puerto Rico-Mayagüez 

Research Summary

We study chromatin — the complex of DNA and proteins that make up our chromosomes. We aim to understand how post-translational modifications to these building-blocks, as well as the factors that regulate these events, play essential roles in maintaining the integrity of cells, tissues, and ultimately entire organisms. We implement a combination of functional genomics, biochemical, genetic, and epigenomic approaches to study how chromatin and epigenetic factors decode the chemical language of chromatin, and how these are dysregulated in diseases such as cancer.

Awards

  • AACR Gertrude B. Elion Cancer Research Award, 2023
  • V Foundation Award, 2022
  • NIH MOSAIC K99/R00 Postdoctoral Career Transition Award, 2021
  • Eddie Méndez Scholar Award, Fred Hutchinson Cancer Research Center, 2020
  • Damon Runyon-Sohn Pediatric Cancer Fellowship, Damon Runyon Cancer Research Foundation, 2017

Key Publications

  1. A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition. Soto-Feliciano, YM, Sánchez-Rivera, FJ, Perner, F, Barrows, DW, Kastenhuber, ER, Ho, YJ, Carroll, T, Xiong, Y, Anand, D, Soshnev, AA et al.. 2023. Cancer Discov 13, 146-169.
    doi: 10.1158/2159-8290.CD-22-0416PMID:36264143
  2. PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Soto-Feliciano, YM, Bartlebaugh, JME, Liu, Y, Sánchez-Rivera, FJ, Bhutkar, A, Weintraub, AS, Buenrostro, JD, Cheng, CS, Regev, A, Jacks, TE et al.. 2017. Genes Dev 31, 973-989.
    doi: 10.1101/gad.295857.117PMID:28607179
  3. A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Meacham, CE, Lawton, LN, Soto-Feliciano, YM, Pritchard, JR, Joughin, BA, Ehrenberger, T, Fenouille, N, Zuber, J, Williams, RT, Young, RA et al.. 2015. Genes Dev 29, 483-8.
    doi: 10.1101/gad.254151.114PMID:25737277

Recent Publications

  1. Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis. Zhuang, X, Wang, Q, Joost, S, Ferrena, A, Humphreys, DT, Li, Z, Blum, M, Bastl, K, Ding, S, Landais, Y et al.. 2024. bioRxiv , .
    doi: 10.1101/2024.06.23.600305PMID:38979280
  2. Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors. Karagiannis, D, Wu, W, Li, A, Hayashi, M, Chen, X, Yip, M, Mangipudy, V, Xu, X, Sánchez-Rivera, FJ, Soto-Feliciano, YM et al.. 2024. Cell Rep 43, 113629.
    doi: 10.1016/j.celrep.2023.113629PMID:38165806
  3. Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma. Chen, X, Li, Y, Zhu, F, Xu, X, Estrella, B, Pazos, MA 2nd, McGuire, JT, Karagiannis, D, Sahu, V, Mustafokulov, M et al.. 2023. Nat Commun 14, 4259.
    doi: 10.1038/s41467-023-39990-5PMID:37460547
  4. MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer. Zhu, C, Soto-Feliciano, YM, Morris, JP, Huang, CH, Koche, RP, Ho, YJ, Banito, A, Chen, CW, Shroff, A, Tian, S et al.. 2023. Elife 12, .
    doi: 10.7554/eLife.80854PMID:37261974
  5. Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors. Karagiannis, D, Wu, W, Li, A, Hayashi, M, Chen, X, Yip, M, Mangipudy, V, Xu, X, Sánchez-Rivera, FJ, Soto-Feliciano, YM et al.. 2023. bioRxiv , .
    doi: 10.1101/2023.04.24.538118PMID:37162970
  6. A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition. Soto-Feliciano, YM, Sánchez-Rivera, FJ, Perner, F, Barrows, DW, Kastenhuber, ER, Ho, YJ, Carroll, T, Xiong, Y, Anand, D, Soshnev, AA et al.. 2023. Cancer Discov 13, 146-169.
    doi: 10.1158/2159-8290.CD-22-0416PMID:36264143
  7. Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Sánchez-Rivera, FJ, Ryan, J, Soto-Feliciano, YM, Clare Beytagh, M, Xuan, L, Feldser, DM, Hemann, MT, Zamudio, J, Dimitrova, N, Letai, A et al.. 2021. Proc Natl Acad Sci U S A 118, .
    doi: 10.1073/pnas.2019740118PMID:34074758
  8. Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors. Hoffmann, HH, Sánchez-Rivera, FJ, Schneider, WM, Luna, JM, Soto-Feliciano, YM, Ashbrook, AW, Le Pen, J, Leal, AA, Ricardo-Lax, I, Michailidis, E et al.. 2021. Cell Host Microbe 29, 267-280.e5.
    doi: 10.1016/j.chom.2020.12.009PMID:33357464
  9. Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function. Jiang, T, Sánchez-Rivera, FJ, Soto-Feliciano, YM, Yang, Q, Song, CQ, Bhuatkar, A, Haynes, CM, Hemann, MT, Xue, W. 2021. Hepatology 74, 233-247.
    doi: 10.1002/hep.31685PMID:33336367
  10. Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors. Hoffmann, HH, Schneider, WM, Sánchez-Rivera, FJ, Luna, JM, Ashbrook, AW, Soto-Feliciano, YM, Leal, AA, Le Pen, J, Ricardo-Lax, I, Michailidis, E et al.. 2020. bioRxiv , .
    doi: 10.1101/2020.09.11.291716PMID:32935098
  11. A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition. Soto-Feliciano YM*, Sánchez-Rivera FJ*, Perner F*, Barrows DW, Kastenhuber E, Ho YJ, Carroll T, Xiong Y, Soshnev A, Gates L, Beytagh MC, Cheon D, Gu S, Liu XS, Krivtsov AV, Meneses M, de Stanchina E, Stone RM, Armstrong SA#, Lowe SW#, Allis CD#. *Co-first author, #Co-corresponding author. 2021. bioRxiv.
    doi: https://doi.org/10.1101/2021.10.22.465184.
More Publications

Multimedia

 

 

Photo credit: Courtesy of Yadira Soto-Feliciano