Education
- PhD, 1987, Case Western Reserve University; MD, 1989, Case Western Reserve University
- BS, 1981, Chemistry with Concentration in Solid-State and Polymer Physics, Cornell University
Research Summary
Our goal is to understand how signaling pathways are integrated at the molecular and systems levels to control cellular responses. We have two main focuses: First, we study signaling pathways and networks that control cell cycle progression and DNA damage responses in cancer and cancer therapy. Second, we examine the cross-talk between inflammation, cytokine signaling and cancer. Much of our work focuses on how modular protein domains and kinases work together to build molecular signaling circuits, and how this information can be used to design synergistic drug combinations for the personalized treatment of human disease.
Awards
- MacVicar Faculty Fellow, 2021
- Fellow, Association of American Physicians, 2021
- Teaching with Digital Technology Award, 2018
More Publications Photo credit: Steve Boxall
