Education
- PhD, 2011, MIT
- BS, 2006, Chemistry, University of Puerto Rico-Río Piedras
Research Summary
We focus on the molecular entities controlling and coordinating RNA metabolism — that is, the compendium of processes that involve RNA, including protein synthesis, processing, modifications, export, translation and degradation. Our goal is to understand how different aspects of RNA metabolism are controlled to generate structure and function during development, as well as how mutations in components of the RNA metabolic program lead to congenital disorders and cancer.Key Publications
- DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis. Shao, Z, Flynn, RA, Crowe, JL, Zhu, Y, Liang, J, Jiang, W, Aryan, F, Aoude, P, Bertozzi, CR, Estes, VM et al.. 2020. Nature 579, 291-296.
doi: 10.1038/s41586-020-2041-2PMID:32103174 - 7SK-BAF axis controls pervasive transcription at enhancers. Flynn, RA, Do, BT, Rubin, AJ, Calo, E, Lee, B, Kuchelmeister, H, Rale, M, Chu, C, Kool, ET, Wysocka, J et al.. 2016. Nat Struct Mol Biol 23, 231-8.
doi: 10.1038/nsmb.3176PMID:26878240 - RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. Calo, E, Flynn, RA, Martin, L, Spitale, RC, Chang, HY, Wysocka, J. 2015. Nature 518, 249-53.
doi: 10.1038/nature13923PMID:25470060 - Modification of enhancer chromatin: what, how, and why? Calo, E, Wysocka, J. 2013. Mol Cell 49, 825-37.
doi: 10.1016/j.molcel.2013.01.038PMID:23473601 - Rb regulates fate choice and lineage commitment in vivo. Calo, E, Quintero-Estades, JA, Danielian, PS, Nedelcu, S, Berman, SD, Lees, JA. 2010. Nature 466, 1110-4.
doi: 10.1038/nature09264PMID:20686481
Recent Publications
- A pH-Centric Model of Nucleolar Activity and Regulation. Detrés, D, Camacho-Badillo, A, Calo, E. 2025. J Mol Biol , 169136.
doi: 10.1016/j.jmb.2025.169136PMID:40216015 - Targeted degradation of CDK9 potently disrupts the MYC-regulated network. Toure, MA, Motoyama, K, Xiang, Y, Urgiles, J, Kabinger, F, Koglin, AS, Iyer, RS, Gagnon, K, Kumar, A, Ojeda, S et al.. 2025. Cell Chem Biol , .
doi: 10.1016/j.chembiol.2025.03.001PMID:40154489 - RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry. Perr, J, Langen, A, Almahayni, K, Nestola, G, Chai, P, Lebedenko, CG, Volk, RF, Detrés, D, Caldwell, RM, Spiekermann, M et al.. 2025. Cell 188, 1878-1895.e25.
doi: 10.1016/j.cell.2025.01.040PMID:40020667 - Reduced EIF6 dosage attenuates TP53 activation in models of Shwachman-Diamond syndrome. Oyarbide, U, Bezzerri, V, Staton, M, Boni, C, Shah, A, Cipolli, M, Calo, E, Corey, SJ. 2025. J Clin Invest 135, .
doi: 10.1172/JCI187778PMID:39964763 - A dual ribosomal system in the zebrafish soma and germline. Shah, AN, Leesch, F, Lorenzo-Orts, L, Grundmann, L, Novatchkova, M, Haselbach, D, Calo, E, Pauli, A. 2024. bioRxiv , .
doi: 10.1101/2024.08.29.610041PMID:39257781 - Targeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network. Toure, MA, Motoyama, K, Xiang, Y, Urgiles, J, Kabinger, F, Koglin, AS, Iyer, RS, Gagnon, K, Kumar, A, Ojeda, S et al.. 2024. bioRxiv , .
doi: 10.1101/2024.05.14.593352PMID:38952800 - A common cellular response to broad splicing perturbations is characterized by metabolic transcript downregulation driven by the Mdm2-p53 axis. Varineau, JE, Calo, E. 2024. Dis Model Mech 17, .
doi: 10.1242/dmm.050356PMID:38426258 - Nucleolus activity-dependent recruitment and biomolecular condensation by pH sensing. Aryan, F, Detrés, D, Luo, CC, Kim, SX, Shah, AN, Bartusel, M, Flynn, RA, Calo, E. 2023. Mol Cell 83, 4413-4423.e10.
doi: 10.1016/j.molcel.2023.10.031PMID:37979585 - SBDSR126T rescues survival of sbds -/- zebrafish in a dose-dependent manner independently of Tp53. Oyarbide, U, Shah, AN, Staton, M, Snyderman, M, Sapra, A, Calo, E, Corey, SJ. 2023. Life Sci Alliance 6, .
doi: 10.26508/lsa.202201856PMID:37816584 - An evolutionarily nascent architecture underlying the formation and emergence of biomolecular condensates. Jaberi-Lashkari, N, Lee, B, Aryan, F, Calo, E. 2023. Cell Rep 42, 112955.
doi: 10.1016/j.celrep.2023.112955PMID:37586369