Education
- PhD, 2011, MIT
- BS, 2006, Chemistry, University of Puerto Rico-Río Piedras
Research Summary
We focus on the molecular entities controlling and coordinating RNA metabolism — that is, the compendium of processes that involve RNA, including protein synthesis, processing, modifications, export, translation and degradation. Our goal is to understand how different aspects of RNA metabolism are controlled to generate structure and function during development, as well as how mutations in components of the RNA metabolic program lead to congenital disorders and cancer.Key Publications
- DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis. Shao, Z, Flynn, RA, Crowe, JL, Zhu, Y, Liang, J, Jiang, W, Aryan, F, Aoude, P, Bertozzi, CR, Estes, VM et al.. 2020. Nature 579, 291-296.
doi: 10.1038/s41586-020-2041-2PMID:32103174 - 7SK-BAF axis controls pervasive transcription at enhancers. Flynn, RA, Do, BT, Rubin, AJ, Calo, E, Lee, B, Kuchelmeister, H, Rale, M, Chu, C, Kool, ET, Wysocka, J et al.. 2016. Nat Struct Mol Biol 23, 231-8.
doi: 10.1038/nsmb.3176PMID:26878240 - RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. Calo, E, Flynn, RA, Martin, L, Spitale, RC, Chang, HY, Wysocka, J. 2015. Nature 518, 249-53.
doi: 10.1038/nature13923PMID:25470060 - Modification of enhancer chromatin: what, how, and why? Calo, E, Wysocka, J. 2013. Mol Cell 49, 825-37.
doi: 10.1016/j.molcel.2013.01.038PMID:23473601 - Rb regulates fate choice and lineage commitment in vivo. Calo, E, Quintero-Estades, JA, Danielian, PS, Nedelcu, S, Berman, SD, Lees, JA. 2010. Nature 466, 1110-4.
doi: 10.1038/nature09264PMID:20686481