David Housman

David Housman

Virginia and D.K. Ludwig Scholar for Cancer Research; Intramural Faculty, Koch Institute

David Housman studies the biological underpinnings of diseases like Huntington’s, cancer, and cardiovascular disease.

617-253-3013

Phone

76-553

Office

dhousman@mit.edu

Email

Koch Institute for Integrative Cancer Research

Location

Lab Website
Elizabeth Galoyan

Assistant

617-253-3016

Assistant Phone

Education

  • PhD, 1971, Brandeis University
  • BS, 1966, Biology, Brandeis University

Research Summary

We use genetic approaches to identify the molecular basis of human disease pathology. More specifically, we develop strategies to combat three major disease areas: cancer, trinucleotide repeat disorders like Huntington’s disease, and cardiovascular disease.

Awards

  • National Academy of Medicine, Member, 1997
  • National Academy of Sciences, Member, 1994

Key Publications

  1. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Lowe, SW, Ruley, HE, Jacks, T, Housman, DE. 1993. Cell 74, 957-67.
    doi: 10.1016/0092-8674(93)90719-7PMID:8402885
  2. Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member. Brook, JD, McCurrach, ME, Harley, HG, Buckler, AJ, Church, D, Aburatani, H, Hunter, K, Stanton, VP, Thirion, JP, Hudson, T et al.. 1992. Cell 68, 799-808.
    doi: 10.1016/0092-8674(92)90154-5PMID:1310900
  3. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Call, KM, Glaser, T, Ito, CY, Buckler, AJ, Pelletier, J, Haber, DA, Rose, EA, Kral, A, Yeger, H, Lewis, WH et al.. 1990. Cell 60, 509-20.
    doi: 10.1016/0092-8674(90)90601-aPMID:2154335
  4. High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. Lichter, P, Tang, CJ, Call, K, Hermanson, G, Evans, GA, Housman, D, Ward, DC. 1990. Science 247, 64-9.
    doi: 10.1126/science.2294592PMID:2294592
  5. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Geissler, EN, Ryan, MA, Housman, DE. 1988. Cell 55, 185-92.
    doi: 10.1016/0092-8674(88)90020-7PMID:2458842

Recent Publications

  1. Tenofovir prodrugs potently inhibit Epstein-Barr virus lytic DNA replication by targeting the viral DNA polymerase. Drosu, NC, Edelman, ER, Housman, DE. 2020. Proc Natl Acad Sci U S A 117, 12368-12374.
    doi: 10.1073/pnas.2002392117PMID:32409608
  2. Could antiretrovirals be treating EBV in MS? A case report. Drosu, NC, Edelman, ER, Housman, DE. 2018. Mult Scler Relat Disord 22, 19-21.
    doi: 10.1016/j.msard.2018.02.029PMID:29510325
  3. Genome Sequencing Technologies and Nursing: What Are the Roles of Nurses and Nurse Scientists? Taylor, JY, Wright, ML, Hickey, KT, Housman, DE. 2017. Nurs Res 66, 198-205.
    doi: 10.1097/NNR.0000000000000211PMID:28252579
  4. Lead toxicity and genetics in Flint, MI. Taylor, JY, Wright, ML, Housman, D. 2016. NPJ Genom Med 1, 16018-.
    doi: 10.1038/npjgenmed.2016.18PMID:27398227
  5. Aberrantly spliced HTT, a new player in Huntington's disease pathogenesis. Gipson, TA, Neueder, A, Wexler, NS, Bates, GP, Housman, D. 2013. RNA Biol 10, 1647-52.
    doi: 10.4161/rna.26706PMID:24256709
  6. In vivo identification of therapeutic constructs from pooled candidates in HD model mice. Crook, ZR, Housman, DE. 2013. J Huntingtons Dis 2, 437-41.
    doi: 10.3233/JHD-130073PMID:25062730
  7. Surveying the landscape of Huntington's disease mechanisms, measurements, and medicines. Crook, ZR, Housman, DE. 2013. J Huntingtons Dis 2, 405-36.
    doi: 10.3233/JHD-130072PMID:25062729
  8. Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice. Crook, ZR, Housman, DE. 2012. Proc Natl Acad Sci U S A 109, 7487-92.
    doi: 10.1073/pnas.1204542109PMID:22529362
  9. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Charest, A, Wilker, EW, McLaughlin, ME, Lane, K, Gowda, R, Coven, S, McMahon, K, Kovach, S, Feng, Y, Yaffe, MB et al.. 2006. Cancer Res 66, 7473-81.
    doi: 10.1158/0008-5472.CAN-06-1193PMID:16885344
  10. Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts. Shearman, AM, Cooper, JA, Kotwinski, PJ, Miller, GJ, Humphries, SE, Ardlie, KG, Jordan, B, Irenze, K, Lunetta, KL, Schuit, SC et al.. 2006. Circ Res 98, 590-2.
    doi: 10.1161/01.RES.0000210578.62102.a6PMID:16484614
More Publications
Photo courtesy of David Housman

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