Education
- PhD, 1983, MIT
- BSc, 1979, Medicinal Chemistry, University College London
Research Summary
We study diverse aspects of protein structure and function and employ multidisciplinary approaches to address fundamental problems at the interface of chemistry and biology. We are fascinated by the amazing complexity and myriad functions of glycoconjugates in human health and disease. Still more enthralling are the intricate membrane-associated pathways that lead to the cellular biogenesis of these important macromolecules. Our group applies approaches and technologies from a wide range of synergistic fields including chemical biology (for inhibitor and probe development), biochemistry and biophysics (for analyses within and beyond native and model membranes), and cellular, molecular and microbiology to unravel these pathways. Ultimately we seek to decipher the molecular logic of glycoconjugate biosynthesis and to identify processes to target in the study of infectious disease.
Awards
- National Academy of Sciences, Member, 2010
- Fellow of the Royal Society of Chemistry (FRSC) 2006
- American Chemical Society - Breslow Award for Achievement in Biomimetic Chemistry 2006
- Protein Society - Kaiser Award, 2006
- Margaret MacVicar Faculty Fellow, 2003-2013
- American Academy of Arts and Sciences, Fellow, 2001
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