Stem cells can self-renew and differentiate. Embryonic stem cells, from mammalian blastomeres, can generate all cells of the body and adult stem cells reside in mature tissues where they produce particular adult cells. MIT Biology identifies molecular mechanisms underlying stem cell renewal and differentiation programs, investigates stem cell roles in regeneration, and investigates the potential of stem cells for disease modeling and regenerative medicine. Epigenetics involves changes in phenotype heritable through cell division but not associated with DNA sequence change. Epigenetic mechanisms underlie gene expression and cell state changes during gametogenesis, development, and aging. MIT Biology studies molecular mechanisms of epigenetics, including chromatin regulation, DNA methylation, gene expression networks, and non-coding RNAs.
Faculty with research programs in stem cells and epigenetics: