Dennis Kim

Dennis Kim

Ivan R. Cottrell Professor of Immunology

Dennis Kim considers the relationship between animals and their microbial environment — specifically, how bacteria influence the behavior and physiology of the simple animal host C. elegans.





Sarah Wylie



Assistant Phone


MD/PhD 1997, Harvard University

Research Summary

We are interested in how microbes influence host physiology to shape the evolution of multicellular life. We investigate these processes in Caenorhabditis elegans, a simple animal host. We take a molecular genetic approach to study host physiology, as well as the evolutionarily conserved signaling nexus of innate immunity, stress physiology and aging.

Recent Publications

  1. Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation in. Kulalert, W, Sadeeshkumar, H, Zhang, YK, Schroeder, FC, Kim, DH. 2017. Genetics 206, 251-263.
    doi: 10.1534/genetics.117.200568PMID: 28292919
  2. Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in. Hilbert, ZA, Kim, DH. 2017. Elife 6, .
    doi: 10.7554/eLife.21166PMID: 28117661
  3. Age-Dependent Neuroendocrine Signaling from Sensory Neurons Modulates the Effect of Dietary Restriction on Longevity of Caenorhabditis elegans. Fletcher, M, Kim, DH. 2017. PLoS Genet. 13, e1006544.
    doi: 10.1371/journal.pgen.1006544PMID: 28107363
  4. Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans. Cattie, DJ, Richardson, CE, Reddy, KC, Ness-Cohn, EM, Droste, R, Thompson, MK, Gilbert, WV, Kim, DH. 2016. PLoS Genet. 12, e1006326.
    doi: 10.1371/journal.pgen.1006326PMID: 27690135
  5. IRE1 Sulfenylation by Reactive Oxygen Species Coordinates Cellular Stress Signaling. Kim, DH. 2016. Mol. Cell 63, 541-542.
    doi: 10.1016/j.molcel.2016.08.003PMID: 27540852
  6. Inhibition of Lithium-Sensitive Phosphatase BPNT-1 Causes Selective Neuronal Dysfunction in C. elegans. Meisel, JD, Kim, DH. 2016. Curr. Biol. 26, 1922-8.
    doi: 10.1016/j.cub.2016.05.050PMID: 27397889
  7. Recent Advances in Flexible and Stretchable Bio-Electronic Devices Integrated with Nanomaterials. Choi, S, Lee, H, Ghaffari, R, Hyeon, T, Kim, DH. 2016. Adv. Mater. Weinheim 28, 4203-18.
    doi: 10.1002/adma.201504150PMID: 26779680
  8. Signal Transduction: A Different Kind of Toll Is in the BAG. Kim, DH. 2015. Curr. Biol. 25, R767-9.
    doi: 10.1016/j.cub.2015.06.057PMID: 26325140
  9. Tissue expression pattern of PMK-2 p38 MAPK is established by the miR-58 family in C. elegans. Pagano, DJ, Kingston, ER, Kim, DH. 2015. PLoS Genet. 11, e1004997.
    doi: 10.1371/journal.pgen.1004997PMID: 25671546
  10. Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans. Meisel, JD, Panda, O, Mahanti, P, Schroeder, FC, Kim, DH. 2014. Cell 159, 267-80.
    doi: 10.1016/j.cell.2014.09.011PMID: 25303524
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