David Sabatini

David Sabatini

Professor of Biology; Member, Whitehead Institute; Investigator, Howard Hughes Medical Institute; Senior Member, Broad Institute; Member, Koch Institute for Integrative Cancer Research; American Cancer Society Research Professor

David Sabatini studies the pathways that regulate growth and metabolism and how they are deregulated in diseases like cancer and diabetes.

617-258-6407

Phone

WI-661

Office

Edith Valeri

Assistant

617-258-6276

Assistant Phone

Education

  • MD/PhD, 1997, Johns Hopkins School of Medicine
  • BS, 1990, Biochemistry, Brown University

Research Summary

We probe the basic mechanisms that regulate growth — the process whereby cells and organisms accumulate mass and increase in size. The pathways that control growth are often hindered in human diseases like diabetes and cancer. Our long-term goals are to identify and characterize these mechanisms, and to understand their roles in normal and diseased mammals.

Awards

  • Sjöberg Prize, Royal Swedish Academy of Sciences, 2020
  • Frontiers of Knowledge Award in Biology and Biomedicine, 2020
  • Louisa Gross Horwitz Prize, Columbia University, 2019
  • Switzer Prize, 2018
  • Dickson Prize in Medicine, 2017
  • Lurie Prize in Biomedical Sciences, 2017
  • National Academy of Sciences, Member, 2016
  • National Academy of Sciences, Award in Molecular Biology, 2014
  • Howard Hughes Medical Institute, HHMI Investigator, 2008
  • Charles Ross Scholar Award, 2003-2005

Key Publications

  1. Twenty-five years of mTOR: Uncovering the link from nutrients to growth. Sabatini, DM. 2017. Proc Natl Acad Sci U S A 114, 11818-11825.
    doi: 10.1073/pnas.1716173114PMID:29078414
  2. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Wang, T, Yu, H, Hughes, NW, Liu, B, Kendirli, A, Klein, K, Chen, WW, Lander, ES, Sabatini, DM. 2017. Cell 168, 890-903.e15.
    doi: 10.1016/j.cell.2017.01.013PMID:28162770
  3. Mechanism of arginine sensing by CASTOR1 upstream of mTORC1. Saxton, RA, Chantranupong, L, Knockenhauer, KE, Schwartz, TU, Sabatini, DM. 2016. Nature 536, 229-33.
    doi: 10.1038/nature19079PMID:27487210
  4. Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. Saxton, RA, Knockenhauer, KE, Wolfson, RL, Chantranupong, L, Pacold, ME, Wang, T, Schwartz, TU, Sabatini, DM. 2016. Science 351, 53-8.
    doi: 10.1126/science.aad2087PMID:26586190
  5. Sestrin2 is a leucine sensor for the mTORC1 pathway. Wolfson, RL, Chantranupong, L, Saxton, RA, Shen, K, Scaria, SM, Cantor, JR, Sabatini, DM. 2016. Science 351, 43-8.
    doi: 10.1126/science.aab2674PMID:26449471

Recent Publications

  1. MCART1/SLC25A51 is required for mitochondrial NAD transport. Kory, N, Uit de Bos, J, van der Rijt, S, Jankovic, N, Güra, M, Arp, N, Pena, IA, Prakash, G, Chan, SH, Kunchok, T et al.. 2020. Sci Adv 6, .
    doi: 10.1126/sciadv.abe5310PMID:33087354
  2. Dihydroxyacetone phosphate signals glucose availability to mTORC1. Orozco, JM, Krawczyk, PA, Scaria, SM, Cangelosi, AL, Chan, SH, Kunchok, T, Lewis, CA, Sabatini, DM. 2020. Nat Metab 2, 893-901.
    doi: 10.1038/s42255-020-0250-5PMID:32719541
  3. A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells. Ray, GJ, Boydston, EA, Shortt, E, Wyant, GA, Lourido, S, Chen, WW, Sabatini, DM. 2020. iScience 23, 101109.
    doi: 10.1016/j.isci.2020.101109PMID:32417403
  4. Author Correction: Tumours with PI3K activation are resistant to dietary restriction. Kalaany, NY, Sabatini, DM. 2020. Nature 581, E2.
    doi: 10.1038/s41586-020-2215-yPMID:32405003
  5. Dietary modifications for enhanced cancer therapy. Kanarek, N, Petrova, B, Sabatini, DM. 2020. Nature 579, 507-517.
    doi: 10.1038/s41586-020-2124-0PMID:32214253
  6. Author Correction: mTOR at the nexus of nutrition, growth, ageing and disease. Liu, GY, Sabatini, DM. 2020. Nat Rev Mol Cell Biol 21, 246.
    doi: 10.1038/s41580-020-0219-yPMID:32005970
  7. Author Correction: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Chivukula, RR, Montoro, DT, Leung, HM, Yang, J, Shamseldin, HE, Taylor, MS, Dougherty, GW, Zariwala, MA, Carson, J, Daniels, MLA et al.. 2020. Nat Med 26, 300.
    doi: 10.1038/s41591-020-0773-zPMID:31996837
  8. A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Chivukula, RR, Montoro, DT, Leung, HM, Yang, J, Shamseldin, HE, Taylor, MS, Dougherty, GW, Zariwala, MA, Carson, J, Daniels, MLA et al.. 2020. Nat Med 26, 244-251.
    doi: 10.1038/s41591-019-0730-xPMID:31959991
  9. mTOR at the nexus of nutrition, growth, ageing and disease. Liu, GY, Sabatini, DM. 2020. Nat Rev Mol Cell Biol 21, 183-203.
    doi: 10.1038/s41580-019-0199-yPMID:31937935
  10. Nutrient regulation of mTORC1 at a glance. Condon, KJ, Sabatini, DM. 2019. J Cell Sci 132, .
    doi: 10.1242/jcs.222570PMID:31722960
More Publications

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Photo credit: Gretchen Ertl/Whitehead Institute