Aviv Regev

Aviv Regev

Professor of Biology; Core Member, Broad Institute; Investigator, Howard Hughes Medical Institute

Aviv Regev pioneers the use of single-cell genomics and other techniques to dissect the molecular networks that regulate genes, define cells and tissues, and influence health and disease.

617-714-7021

Phone

NE30-6031

Office

Kate Mulherin

Assistant

617-714-7022

Assistant Phone

Education

  • PhD, 2003, Tel Aviv University
  • MS, 1997, Tel Aviv University

Research Summary

We are interested in biological networks, gene regulation and evolution. Our work focuses on dissecting complex molecular networks to determine how they function and evolve in the face of genetic and environmental changes, as well as during differentiation, evolution and disease. The Regev lab is no longer accepting students.

Awards

  • Jonathan Kraft Prize for Excellence in Cancer Research, Massachusetts General Hospital Center for Cancer Research, 2021
  • American Association for Cancer Research Academy, Fellow, 2021
  • National Academy of Medicine, Member, 2020
  • James Prize in Science and Technology Integration, National Academy of Sciences, 2020
  • Lurie Prize in Biomedical Sciences, Foundation for the National Institutes of Health, 2020
  • National Academy of Sciences, Member, 2019
  • Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Center, 2017
  • International Society for Computational Biology (ISCB) Innovator Award, 2017
  • ISCB Fellow, 2016
  • Earl and Thressa Stadtman Scholar Award, 2014
  • Howard Hughes Medical Institute, HHMI Investigator, 2013
  • NIH Director’s Pioneer Award, 2008
  • Sloan Research Fellowship, 2008
  • Overton Prize, 2008

Recent Publications

  1. Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics. Jagadeesh, KA, Dey, KK, Montoro, DT, Mohan, R, Gazal, S, Engreitz, JM, Xavier, RJ, Price, AL, Regev, A. 2022. Nat Genet 54, 1479-1492.
    doi: 10.1038/s41588-022-01187-9PMID:36175791
  2. Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment. Hwang, WL, Jagadeesh, KA, Guo, JA, Hoffman, HI, Yadollahpour, P, Reeves, JW, Mohan, R, Drokhlyansky, E, Van Wittenberghe, N, Ashenberg, O et al.. 2022. Nat Genet 54, 1178-1191.
    doi: 10.1038/s41588-022-01134-8PMID:35902743
  3. Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function. Eraslan, G, Drokhlyansky, E, Anand, S, Fiskin, E, Subramanian, A, Slyper, M, Wang, J, Van Wittenberghe, N, Rouhana, JM, Waldman, J et al.. 2022. Science 376, eabl4290.
    doi: 10.1126/science.abl4290PMID:35549429
  4. DIALOGUE maps multicellular programs in tissue from single-cell or spatial transcriptomics data. Jerby-Arnon, L, Regev, A. 2022. Nat Biotechnol 40, 1467-1477.
    doi: 10.1038/s41587-022-01288-0PMID:35513526
  5. The evolution, evolvability and engineering of gene regulatory DNA. Vaishnav, ED, de Boer, CG, Molinet, J, Yassour, M, Fan, L, Adiconis, X, Thompson, DA, Levin, JZ, Cubillos, FA, Regev, A et al.. 2022. Nature 603, 455-463.
    doi: 10.1038/s41586-022-04506-6PMID:35264797
  6. SM-Omics is an automated platform for high-throughput spatial multi-omics. Vickovic, S, Lötstedt, B, Klughammer, J, Mages, S, Segerstolpe, Å, Rozenblatt-Rosen, O, Regev, A. 2022. Nat Commun 13, 795.
    doi: 10.1038/s41467-022-28445-yPMID:35145087
  7. Single-cell profiling of proteins and chromatin accessibility using PHAGE-ATAC. Fiskin, E, Lareau, CA, Ludwig, LS, Eraslan, G, Liu, F, Ring, AM, Xavier, RJ, Regev, A. 2022. Nat Biotechnol 40, 374-381.
    doi: 10.1038/s41587-021-01065-5PMID:34675424
  8. Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer. Ouspenskaia, T, Law, T, Clauser, KR, Klaeger, S, Sarkizova, S, Aguet, F, Li, B, Christian, E, Knisbacher, BA, Le, PM et al.. 2022. Nat Biotechnol 40, 209-217.
    doi: 10.1038/s41587-021-01021-3PMID:34663921
  9. Joint single-cell measurements of nuclear proteins and RNA in vivo. Chung, H, Parkhurst, CN, Magee, EM, Phillips, D, Habibi, E, Chen, F, Yeung, BZ, Waldman, J, Artis, D, Regev, A et al.. 2021. Nat Methods 18, 1204-1212.
    doi: 10.1038/s41592-021-01278-1PMID:34608310
  10. A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies. Chen, X, Gentili, M, Hacohen, N, Regev, A. 2021. Nat Commun 12, 5506.
    doi: 10.1038/s41467-021-25777-zPMID:34535642
More Publications

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Photo credit: Casey Atkins