Aviv Regev

Aviv Regev

Professor of Biology; Core Member, Broad Institute; Investigator, Howard Hughes Medical Institute

Aviv Regev pioneers the use of single-cell genomics and other techniques to dissect the molecular networks that regulate genes, define cells and tissues, and influence health and disease.

617-714-7021

Phone

NE30-6031

Office

Kate Mulherin

Assistant

617-714-7022

Assistant Phone

Education

PhD 2003, Tel Aviv University

Research Summary

We are interested in biological networks, gene regulation and evolution. Our work focuses on dissecting complex molecular networks to determine how they function and evolve in the face of genetic and environmental changes, as well as during differentiation, evolution and disease.

Awards

  • Memorial Sloan Kettering Cancer Center Paul Marks Prize for Cancer Research, 2017
  • International Society for Computational Biology (ISCB) Innovator Award, 2017
  • ISCB Fellow, 2016
  • Earl and Thressa Stadtman Scholar Award, 2014
  • Howard Hughes Medical Institute, HHMI Investigator, 2013
  • NIH Director’s Pioneer Award, 2008
  • Sloan Research Fellowship, 2008
  • Overton Prize, 2008

Recent Publications

  1. Genetic determinants of co-accessible chromatin regions in activated T cells across humans. Gate, RE, Cheng, CS, Aiden, AP, Siba, A, Tabaka, M, Lituiev, D, Machol, I, Gordon, MG, Subramaniam, M, Shamim, M et al.. 2018. Nat. Genet. 50, 1140-1150.
    doi: 10.1038/s41588-018-0156-2PMID:29988122
  2. BROCKMAN: deciphering variance in epigenomic regulators by k-mer factorization. de Boer, CG, Regev, A. 2018. BMC Bioinformatics 19, 253.
    doi: 10.1186/s12859-018-2255-6PMID:29970004
  3. Efficient Generation of Transcriptomic Profiles by Random Composite Measurements. Cleary, B, Cong, L, Cheung, A, Lander, ES, Regev, A. 2017. Cell 171, 1424-1436.e18.
    doi: 10.1016/j.cell.2017.10.023PMID:29153835
  4. A single-cell survey of the small intestinal epithelium. Haber, AL, Biton, M, Rogel, N, Herbst, RH, Shekhar, K, Smillie, C, Burgin, G, Delorey, TM, Howitt, MR, Katz, Y et al.. 2017. Nature 551, 333-339.
    doi: 10.1038/nature24489PMID:29144463
  5. Massively parallel single-nucleus RNA-seq with DroNc-seq. Habib, N, Avraham-Davidi, I, Basu, A, Burks, T, Shekhar, K, Hofree, M, Choudhury, SR, Aguet, F, Gelfand, E, Ardlie, K et al.. 2017. Nat. Methods 14, 955-958.
    doi: 10.1038/nmeth.4407PMID:28846088
  6. Scaling single-cell genomics from phenomenology to mechanism. Tanay, A, Regev, A. 2017. Nature 541, 331-338.
    doi: 10.1038/nature21350PMID:28102262
  7. Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens. Dixit, A, Parnas, O, Li, B, Chen, J, Fulco, CP, Jerby-Arnon, L, Marjanovic, ND, Dionne, D, Burks, T, Raychowdhury, R et al.. 2016. Cell 167, 1853-1866.e17.
    doi: 10.1016/j.cell.2016.11.038PMID:27984732
  8. Writ large: Genomic dissection of the effect of cellular environment on immune response. Yosef, N, Regev, A. 2016. Science 354, 64-68.
    doi: 10.1126/science.aaf5453PMID:27846493
  9. Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons. Habib, N, Li, Y, Heidenreich, M, Swiech, L, Avraham-Davidi, I, Trombetta, JJ, Hession, C, Zhang, F, Regev, A. 2016. Science 353, 925-8.
    doi: 10.1126/science.aad7038PMID:27471252
  10. Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity. Gaublomme, JT, Yosef, N, Lee, Y, Gertner, RS, Yang, LV, Wu, C, Pandolfi, PP, Mak, T, Satija, R, Shalek, AK et al.. 2015. Cell 163, 1400-12.
    doi: 10.1016/j.cell.2015.11.009PMID:26607794
More Publications

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Photo credit: Casey Atkins