Richard O. Hynes

Richard O. Hynes

Daniel K. Ludwig Professor for Cancer Research; Intramural Faculty, Koch Institute; Investigator, Howard Hughes Medical Institute

Richard O. Hynes investigates the network of proteins surrounding cells to understand its roles in the spread of cancer throughout the body.

617-253-6422

Phone

76-361

Office

rohynes@mit.edu

Email

Koch Institute for Integrative Cancer Research

Location

Lab Website
rhynes-admin@mit.edu

Assistant

Education

  • PhD, 1971, MIT
  • MA, 1970, Biochemistry, Cambridge University
  • BA, 1966, Biochemistry, Cambridge University

Research Summary

We study the mechanisms underlying the spread of tumor cells throughout the body, known as metastasis. We are particularly interested in the role of the extracellular matrix — a fibrillar meshwork of proteins that surrounds both normal and tumor cells, which plays many important roles in tumor progression. We also investigate changes in the metastatic cells themselves and in the contributions of normal cells, both in terms of metastasis and other bodily functions.

Awards

  • Paget-Ewing Award, Metastasis Research Society, 2018
  • Inaugural American Society for Cell Biology (ASCB) Fellow, 2016
  • American Association for Cancer Research (AACR) Academy, Fellow, 2014
  • Distinguished Investigator Award, International Society for Matrix Biology, 2012
  • Earl Benditt Award, North American Vascular Biology Organization, 2010
  • Robert and Claire Pasarow Medical Research Award – Cardiovascular, 2008
  • E.B. Wilson Medal, American Society for Cell Biology, 2007
  • President, American Society for Cell Biology, 2000
  • Gairdner Foundation International Award, 1997
  • National Academy of Sciences, Member, 1996
  • National Academy of Medicine, Member, 1995
  • Royal Society of London, Fellow, 1989
  • Howard Hughes Medical Institute, HHMI Investigator, 1988
  • American Association for the Advancement of Science, Fellow, 1987
  • American Academy of Arts and Sciences, Fellow, 1987
  • John Simon Guggenheim Memorial Foundation, Guggenheim Fellowship, 1982

Media Inquiries

For media inquiries, please email rhynes-admin@mit.edu.

Key Publications

  1. YAP Enhances Tumor Cell Dissemination by Promoting Intravascular Motility and Reentry into Systemic Circulation. Benjamin, DC, Kang, JH, Hamza, B, King, EM, Lamar, JM, Manalis, SR, Hynes, RO. 2020. Cancer Res 80, 3867-3879.
    doi: 10.1158/0008-5472.CAN-20-0212PMID:32591412
  2. Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma. Tian, C, Öhlund, D, Rickelt, S, Lidström, T, Huang, Y, Hao, L, Zhao, RT, Franklin, O, Bhatia, SN, Tuveson, DA et al.. 2020. Cancer Res 80, 1461-1474.
    doi: 10.1158/0008-5472.CAN-19-2578PMID:32029550
  3. Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches. Hebert, JD, Myers, SA, Naba, A, Abbruzzese, G, Lamar, JM, Carr, SA, Hynes, RO. 2020. Cancer Res 80, 1475-1485.
    doi: 10.1158/0008-5472.CAN-19-2961PMID:32019869
  4. Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells. Tian, C, Clauser, KR, Öhlund, D, Rickelt, S, Huang, Y, Gupta, M, Mani, DR, Carr, SA, Tuveson, DA, Hynes, RO et al.. 2019. Proc Natl Acad Sci U S A 116, 19609-19618.
    doi: 10.1073/pnas.1908626116PMID:31484774
  5. Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix. Jailkhani, N, Ingram, JR, Rashidian, M, Rickelt, S, Tian, C, Mak, H, Jiang, Z, Ploegh, HL, Hynes, RO. 2019. Proc Natl Acad Sci U S A 116, 14181-14190.
    doi: 10.1073/pnas.1817442116PMID:31068469

Recent Publications

  1. Proteomic Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases. Jailkhani, N, Clauser, KR, Mak, HH, Rickelt, S, Tian, C, Whittaker, CA, Tanabe, KK, Purdy, SR, Carr, SA, Hynes, RO et al.. 2023. Cancer Res 83, 2052-2065.
    doi: 10.1158/0008-5472.CAN-22-1532PMID:37098922
  2. Intratumoral nanobody-IL-2 fusions that bind the tumor extracellular matrix suppress solid tumor growth in mice. Lutz, EA, Jailkhani, N, Momin, N, Huang, Y, Sheen, A, Kang, BH, Wittrup, KD, Hynes, RO. 2022. PNAS Nexus 1, pgac244.
    doi: 10.1093/pnasnexus/pgac244PMID:36712341
  3. Agrin Loss in Barrett's Esophagus-Related Neoplasia and Its Utility as a Diagnostic and Predictive Biomarker. Rickelt, S, Neyaz, A, Condon, C, Whittaker, CA, Zaidi, AH, Taylor, MS, Abbruzzese, G, Mattia, AR, Zukerberg, L, Shroff, SG et al.. 2022. Clin Cancer Res 28, 1167-1179.
    doi: 10.1158/1078-0432.CCR-21-2822PMID:34785582
  4. Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells. Tian, C, Huang, Y, Clauser, KR, Rickelt, S, Lau, AN, Carr, SA, Vander Heiden, MG, Hynes, RO. 2021. Nat Commun 12, 2328.
    doi: 10.1038/s41467-021-22490-9PMID:33879793
  5. YAP Enhances Tumor Cell Dissemination by Promoting Intravascular Motility and Reentry into Systemic Circulation. Benjamin, DC, Kang, JH, Hamza, B, King, EM, Lamar, JM, Manalis, SR, Hynes, RO. 2020. Cancer Res 80, 3867-3879.
    doi: 10.1158/0008-5472.CAN-20-0212PMID:32591412
  6. The scaffold protein IQGAP1 is crucial for extravasation and metastasis. Hebert, JD, Tian, C, Lamar, JM, Rickelt, S, Abbruzzese, G, Liu, X, Hynes, RO. 2020. Sci Rep 10, 2439.
    doi: 10.1038/s41598-020-59438-wPMID:32051509
  7. Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma. Tian, C, Öhlund, D, Rickelt, S, Lidström, T, Huang, Y, Hao, L, Zhao, RT, Franklin, O, Bhatia, SN, Tuveson, DA et al.. 2020. Cancer Res 80, 1461-1474.
    doi: 10.1158/0008-5472.CAN-19-2578PMID:32029550
  8. Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches. Hebert, JD, Myers, SA, Naba, A, Abbruzzese, G, Lamar, JM, Carr, SA, Hynes, RO. 2020. Cancer Res 80, 1475-1485.
    doi: 10.1158/0008-5472.CAN-19-2961PMID:32019869
  9. Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions. Rickelt, S, Condon, C, Mana, M, Whittaker, C, Pfirschke, C, Roper, J, Patil, DT, Brown, I, Mattia, AR, Zukerberg, L et al.. 2020. Clin Cancer Res 26, 1277-1287.
    doi: 10.1158/1078-0432.CCR-19-2898PMID:31852835
  10. Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells. Tian, C, Clauser, KR, Öhlund, D, Rickelt, S, Huang, Y, Gupta, M, Mani, DR, Carr, SA, Tuveson, DA, Hynes, RO et al.. 2019. Proc Natl Acad Sci U S A 116, 19609-19618.
    doi: 10.1073/pnas.1908626116PMID:31484774
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