Education
- Postdoctoral training with Michael Sela, Herman Eisen, and Rodney Porter
- MD, 1959, Yale School of Medicine
- MA, 1956, Mathematics, Radcliffe College
- BA, 1954, Mathematics, Swarthmore College
Research Summary
Lisa Steiner explored the range of structural variation among antibodies in vertebrate species. The variation observed demonstrates that effective antibodies, while sharing certain basic features such as variable and constant regions, can be unexpectedly diverse in structure, varying in number of polypeptide chains or in pattern of disulfide bridging. Moreover, the polypeptide chains in non-mammalian vertebrates do not generally fall into classifications developed for mammalian antibodies, such as kappa, lambda, gamma, etc. Francois Jacob has called such variability “evolutionary tinkering.” Lisa Steiner is no longer accepting students.Key Publications
- Expression of zebrafish rag genes during early development identifies the thymus. Willett, CE, Zapata, AG, Hopkins, N, Steiner, LA. 1997. Dev Biol 182, 331-41.
doi: 10.1006/dbio.1996.8446PMID:9070331 - Characterization and expression of the recombination activating genes (rag1 and rag2) of zebrafish. Willett, CE, Cherry, JJ, Steiner, LA. 1997. Immunogenetics 45, 394-404.
doi: 10.1007/s002510050221PMID:9089097 - Immunoglobulin disulfide bridges: theme and variations. Steiner, LA. 1985. Biosci Rep 5, 973-89.
doi: 10.1007/BF01119910PMID:3938301 - An immunochemical approach to the structure of myosin and the thick filament. Lowey, S, Steiner, LA. 1972. J Mol Biol 65, 111-26.
doi: 10.1016/0022-2836(72)90495-0PMID:4259745 - Sequential changes in the relative affinity of antibodies synthesized during the immune response. Steiner, LA, Eisen, HN. 1967. J Exp Med 126, 1161-83.
doi: 10.1084/jem.126.6.1161PMID:4168368